LCK

Gene Symbol	LCK
Entrez Gene	3932
Alt Symbol	IMD22, LSK, YT16, p56lck, pp58lck
Species	Human
Gene Type	protein-coding
Description	LCK proto-oncogene, Src family tyrosine kinase
Other Description	T-lymphocyte specific protein tyrosine kinase p56lck|leukocyte C-terminal Src kinase|lymphocyte cell-specific protein-tyrosine kinase|lymphocyte-specific protein tyrosine kinase|p56(LSTRA) protein-tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK|t cell-specific protein-tyrosine kinase|tyrosine-protein kinase Lck
Swissprots	P07100 Q12850 Q7RTZ3 Q9NYT8 Q13152 Q5TDH9 Q5TDH8 P06239 D3DPP8 Q96DW4
Accessions	AAA59501 AAA59503 CAA32211 CAD55807 EAX07542 EAX07543 EAX07544 EAX07545 EAX07546 P06239 AA747421 AF228313 AAF34794 AJ865079 CAI23831 AK098027 BAG53565 AK303073 BAG64189 BC013200 AAH13200 DA007906 DB122062 DB129997 DQ891675 ABM82601 DQ894861 ABM85787 HY261581 M36881 AAA59502 U07236 AAA18225 X04476 CAA28165 X05027 CAA28691 X06369 CAA29667 X13529 CAA31884 XM_011541453 XP_011539755 XM_011541454 XP_011539756 XM_011541455 XP_011539757 NM_001042771 NP_001036236 NM_005356 NP_005347
Function	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited,
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12218089}. Cell membrane {ECO:0000269|PubMed:12218089}; Lipid-anchor {ECO:0000269|PubMed:12218089}; Cytoplasmic side {ECO:0000269|PubMed:12218089}. Note=Present in lipid rafts in an inactive form.
Tissue Specificity	Expressed specifically in lymphoid cells.
Top Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Lck full length protein - ab79626 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human Lck full length protein - ab60305 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human Lck full length protein - ab82185 from Abcam Category Protein Prices $275.00 Sizes 10 µg Source E. coli Species Human

Human Lck protein fragment - ab90189 from Abcam Category Protein Source E. coli Species Human

Lck peptide - ab52217 from Abcam Category Peptide

Lck Partial Recombinant Protein - H00003932-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lck Recombinant Protein - H00003932-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lck Recombinant Protein - P4217 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human Lck Protein - P4714 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant Lck Protein - NBP1-99486 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Lck Peptide - P2755 from Novus Biologicals Category Peptide Species Human

LCK-Antibody-C-term-Blocking-Peptide - BP2831c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LCK-Antibody-N-term-Blocking-peptide - BP7712a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Lck (Active) recombinant protein - GTX65154 from GeneTex Category Protein Prices $249.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active Lck, CF - 3704-KS-010 from R&D Systems Category Protein

Human LCK protein - orb244336 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Lck Blocking Peptide - 33R-10503 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

Lck Blocking Peptide - 33R-10785 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

LCK Blocking Peptide - 33R-7352 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Lck protein - 30R-2848 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

LCK (phospho-Tyr393) Blocking Peptide - abx062867 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig, Sheep

LCK Blocking Peptide - abx062868 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig, Sheep

LCK Peptide - AC21-2651-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LCK - H00003932-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LCK - H00003932-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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