LCK

Gene Symbol LCK
Entrez Gene 3932
Alt Symbol IMD22, LSK, YT16, p56lck, pp58lck
Species Human
Gene Type protein-coding
Description LCK proto-oncogene, Src family tyrosine kinase
Other Description T-lymphocyte specific protein tyrosine kinase p56lck|leukocyte C-terminal Src kinase|lymphocyte cell-specific protein-tyrosine kinase|lymphocyte-specific protein tyrosine kinase|p56(LSTRA) protein-tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK|t cell-specific protein-tyrosine kinase|tyrosine-protein kinase Lck
Swissprots P07100 Q12850 Q7RTZ3 Q9NYT8 Q13152 Q5TDH9 Q5TDH8 P06239 D3DPP8 Q96DW4
Accessions AAA59501 AAA59503 CAA32211 CAD55807 EAX07542 EAX07543 EAX07544 EAX07545 EAX07546 P06239 AA747421 AF228313 AAF34794 AJ865079 CAI23831 AK098027 BAG53565 AK303073 BAG64189 BC013200 AAH13200 DA007906 DB122062 DB129997 DQ891675 ABM82601 DQ894861 ABM85787 HY261581 M36881 AAA59502 U07236 AAA18225 X04476 CAA28165 X05027 CAA28691 X06369 CAA29667 X13529 CAA31884 XM_011541453 XP_011539755 XM_011541454 XP_011539756 XM_011541455 XP_011539757 NM_001042771 NP_001036236 NM_005356 NP_005347
Function Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited,
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12218089}. Cell membrane {ECO:0000269|PubMed:12218089}; Lipid-anchor {ECO:0000269|PubMed:12218089}; Cytoplasmic side {ECO:0000269|PubMed:12218089}. Note=Present in lipid rafts in an inactive form.
Tissue Specificity Expressed specifically in lymphoid cells.
Top Pathways Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Primary immunodeficiency, Osteoclast differentiation, HTLV-I infection

PathScan® Phospho-Lck (Tyr505) Sandwich ELISA Antibody Pair - 7993 from Cell Signaling Technology

Category Antibody Pair
Prices $459.00
Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Phospho-Lck (Tyr505) Sandwich ELISA Kit - 7941 from Cell Signaling Technology

Category ELISA Kit
Prices $489.00
Sizes 1 kit (96 assays)

HTScan® Lck Kinase Assay Kit - 7758 from Cell Signaling Technology

Category Assay Kit
Figure 1. Lck kinase activity was measured in a radiometric assay using the following reaction conditions: 5 mM MOPS, pH 7.2, 2.5 mM β-glycerophosphate, 1 mM EGTA, 0.4 mM EDTA, 5 mM MgCl2, 0.05 mM DTT, 50 μM ATP, Substrate: Poly (EY 4:1) 400 ng/μL, and variable amount of Lck kinase.

Phosphotyrosine LCK / Tyrosine-protein Kinase Lck ELISA Kit - RAB0974 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Tyrosine-protein kinase Lck (LCK), Human, ELISA Kit - E01T0623 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

LCK (Human) IP-WB Antibody Pair - H00003932-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

LCK (Human) Matched Antibody Pair - H00003932-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Human Phospho-LCK (Y394) ELISA - PEL-LCK-Y394 from RayBiotech

Category ELISA Kit
Prices $481.00, $866.00, $1,924.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit
LCK (Y394) - Positive Control

Lck Colorimetric Cell-Based ELISA Kit - CB5415 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Lck (Phospho-Tyr505) Colorimetric Cell-Based ELISA Kit - CBP1174 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Lck (Phospho-Tyr192) Colorimetric Cell-Based ELISA Kit - CBP1175 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Lck (Phospho-Tyr393) Colorimetric Cell-Based ELISA Kit - CBP1604 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

lymphocyte-specific protein tyrosine kinase, ELISA Kit - MBS9339843 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine protein kinase Lck (LCK), ELISA Kit - MBS7240514 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 ng/mL.

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7219221 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7242290 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7239734 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7238227 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7248236 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7233396 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7232407 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7245978 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7218144 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 ng/mL.

Tyrosine-protein kinase Lck (LCK), ELISA Kit - MBS7222242 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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