Gene Symbol | ACY3 |
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Entrez Gene | 91703 |
Alt Symbol | ACY-3, HCBP1 |
Species | Human |
Gene Type | protein-coding |
Description | aminoacylase 3 |
Other Description | HCV core-binding protein 1|N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)|acylase III|aminoacylase-3|aspartoacylase (aminoacylase) 3|aspartoacylase (aminocyclase) 3|aspartoacylase-2|hepatitis C virus core-binding protein 1 |
Swissprots | Q96HD9 |
Accessions | EAW74663 EAW74664 Q96HD9 AF359506 AAM00248 AK308710 AY032593 AAK51135 AY040761 AAK94770 AY169233 AAN87896 BC008689 AAH08689 HQ447856 ADQ32340 XM_011545349 XP_011543651 XM_011545350 XP_011543652 XM_011545351 XP_011543653 NM_080658 NP_542389 |
Function | Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity). {ECO:0000250}. |
Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:19486448}; Peripheral membrane protein {ECO:0000269|PubMed:19486448}. Cytoplasm {ECO:0000269|PubMed:19486448}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. |
Aspartoacylase-3 CRISPR/Cas9 KO Plasmid (h) - sc-410231 from Santa Cruz Biotechnology
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Aspartoacylase-3 HDR Plasmid (h) - sc-410231-HDR from Santa Cruz Biotechnology
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Aspartoacylase-3 Double Nickase Plasmid (h) - sc-410231-NIC from Santa Cruz Biotechnology
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Aspartoacylase-3 Double Nickase Plasmid (h2) - sc-410231-NIC-2 from Santa Cruz Biotechnology
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Aspartoacylase-3 CRISPR Activation Plasmid (h) - sc-410231-ACT from Santa Cruz Biotechnology
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Aspartoacylase-3 CRISPR Activation Plasmid (h2) - sc-410231-ACT-2 from Santa Cruz Biotechnology
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Aspartoacylase-3 Lentiviral Activation Particles (h) - sc-410231-LAC from Santa Cruz Biotechnology
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Aspartoacylase-3 Lentiviral Activation Particles (h2) - sc-410231-LAC-2 from Santa Cruz Biotechnology
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Aspartoacylase-3 siRNA (h) - sc-96717 from Santa Cruz Biotechnology
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Aspartoacylase-3 shRNA Plasmid (h) - sc-96717-SH from Santa Cruz Biotechnology
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Aspartoacylase-3 shRNA (h) Lentiviral Particles - sc-96717-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2797 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00545 from Sigma-Aldrich
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ACY3 siRNA (Human) - CRJ4070 from Cohesion Biosciences
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ACY3 - MBS828006 from MyBioSource
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shRNA set against Human ACY3 (NM_080658.1) - SHH231298 from Creative biogene
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shRNA set against Human ACY3(NM_080658.1) - SHG037711 from Creative biogene
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Human ACY3 siRNA - orb274571 from Biorbyt
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ACY3 shRNA Plasmid (Human) - CHJ4070 from Cohesion Biosciences
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ACY3 miRNA 3'UTR clone - MiUTR1H-00149 from Creative biogene
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