DTX1

Gene Symbol DTX1
Entrez Gene 1840
Alt Symbol hDx-1
Species Human
Gene Type protein-coding
Description deltex 1, E3 ubiquitin ligase
Other Description E3 ubiquitin-protein ligase DTX1|deltex homolog 1|deltex1|hDTX1|protein deltex-1
Swissprots O60630 Q86Y01 Q9BS04
Accessions EAW98028 EAW98029 Q86Y01 AF053700 AAC06246 BC005816 AAH05816 BC008321 BC048216 AAH48216 XM_011538009 XP_011536311 NM_004416 NP_004407
Function Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}.
Subcellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
Tissue Specificity Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:12753744, ECO:0000269|PubMed:9590294}.
Top Pathways Notch signaling pathway

Human DTX1 / Deltex ELISA Kit (Sandwich ELISA) - LS-F11332 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Protein deltex-1, DTX1, Human, ELISA Kit - E2670h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.156-10 ng/mL

deltex homolog 1 (Drosophila) , ELISA Kit - MBS9339477 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse DTX1 / Deltex ELISA Kit (Custom ELISA) - LS-F19780 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human Protein deltex-1 ELISA Kit - abx251578 from Abbexa

Category ELISA Kit
Range 0.156 ng/ml - 10 ng/ml

Human Protein deltex-1 ELISA Kit - EKE54175 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Sensitivity The minimum detectable dose of this kit is typically less than 0.078 ng/mL
Range 0.156-10 ng/mL

DTX1 - EKH4466 from Nordic BioSite

Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

DTX1 ELISA Kit (Human) (OKEH01661) - OKEH01661 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 0.078 ng/mL
Range 0.156 - 10 ng/mL

Human DTX1 ELISA Kit - E012412 from Biobool

Category ELISA Kit
Sensitivity 0.1 ng/mL.

Human Protein deltex-1 ELISA Kit - EK4534 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Sensitivity less than 0.078ng/mL
Range 0.156-10 ng/mL

deltex-1, ELISA Kit - MBS9428360 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Sensitivity Less than 0.078ng/mL
Range 0.156-10 ng/mL

deltex-1, ELISA Kit - MBS2881704 from MyBioSource

Category ELISA Kit
Prices $380.00, $500.00, $2,170.00, $3,840.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.156-10 ng/mL

Protein deltex-1, ELISA Kit - MBS764063 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/ml
Range 0.156-10ng/ml

Human DTX1 / Deltex ELISA Kit (Sandwich ELISA) - LS-F33555 from LifeSpan Bioscience

Category ELISA Kit
Sensitivity 0.094
Range 0.156-10 ng/ml
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