DTX1
| Gene Symbol | DTX1 |
|---|---|
| Entrez Gene | 1840 |
| Alt Symbol | hDx-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | deltex 1, E3 ubiquitin ligase |
| Other Description | E3 ubiquitin-protein ligase DTX1|deltex homolog 1|deltex1|hDTX1|protein deltex-1 |
| Swissprots | O60630 Q86Y01 Q9BS04 |
| Accessions | EAW98028 EAW98029 Q86Y01 AF053700 AAC06246 BC005816 AAH05816 BC008321 BC048216 AAH48216 XM_011538009 XP_011536311 NM_004416 NP_004407 |
| Function | Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1. {ECO:0000250, ECO:0000269|PubMed:11564735, ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. |
| Tissue Specificity | Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. {ECO:0000269|PubMed:12753744, ECO:0000269|PubMed:9590294}. |
| Top Pathways | Notch signaling pathway |
Human Deltex full length protein - ab158326 from Abcam
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Human Deltex protein fragment - ab158327 from Abcam
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DTX1 / Deltex Antibody Blocking Peptide - LS-E27208 from LifeSpan Bioscience
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DTX1 / Deltex Antibody Blocking Peptide - LS-E13821 from LifeSpan Bioscience
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DTX1 / Deltex Antibody Blocking Peptide - LS-E9855 from LifeSpan Bioscience
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Recombinant Human DTX1 Protein - H00001840-P01 from Novus Biologicals
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Recombinant Human DTX1 Protein - H00001840-Q01 from Novus Biologicals
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DTX1-Antibody-Center-Blocking-Peptide - BP13133c from Abgent, a WuXi AppTec company
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DTX1-Antibody-Center-Blocking-Peptide - BP8923c from Abgent, a WuXi AppTec company
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Deltex1 blocking peptide - GTX88253-PEP from GeneTex
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DTX1 Immunizing peptide - orb17112 from Biorbyt
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Deltex-1 peptide - orb72607 from Biorbyt
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DTX1 Peptide - AC21-2029-P from Abcore
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Deltex-1 / DTX1 - H00001840-P01 from Acris Antibodies
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Deltex-1 / DTX1 - H00001840-Q01-10 from Acris Antibodies
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Deltex-1 / DTX1 - H00001840-Q01-25 from Acris Antibodies
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DTX1 Peptide - 42-248P from ProSci
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DTX1 fusion protein - ag13148 from Proteintech Group
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DTX1 fusion protein - ag13172 from Proteintech Group
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Recombinant Deltex Homolog 1 (DTX1) - RPL451Hu01 from Uscn Life Science Inc.
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Recombinant Deltex Homolog 1 (DTX1) - RPL451Hu01 from Cloud-clone
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Recombinant Human Protein deltex-1(DTX1) - CSB-YP773055HU CSB-EP773055HU CSB-BP773055HU CSB-MP773055HU from Cusabio
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Deltex Homolog 1 Protein (Recombinant) - abx168143 from Abbexa
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DTX1/Deltex-1, Peptide - MBS426457 from MyBioSource
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DTX1 Protein - NBP2-13940PEP from Novus Biologicals
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