THOC7

Gene Symbol THOC7
Entrez Gene 80145
Alt Symbol NIF3L1BP1, fSAP24, hTREX30
Species Human
Gene Type protein-coding
Description THO complex 7
Other Description NIF3L1-binding protein 1|Ngg1 interacting factor 3 like 1 binding protein 1|THO complex 7 homolog|THO complex subunit 7 homolog|functional spliceosome-associated protein 24|ngg1-interacting factor 3-like protein 1-binding protein 1
Swissprots Q9H5H0 Q8WUF2 Q6P1L3 Q6I9Y2
Accessions EAW65418 EAW65419 EAW65420 EAW65421 Q6I9Y2 AF104914 AI391685 AI784549 AK027098 BAB15656 AK225110 BC020599 AAH20599 BC065012 AAH65012 BI914906 CR457373 CAG33654 HQ448116 ADQ32597 HY023143 XM_006713339 XP_006713402 NM_001285387 NP_001272316 NM_001285404 NP_001272333 NM_025075 NP_079351
Function Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23222130}.
Subcellular Location Cytoplasm. Nucleus. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization.
Top Pathways RNA transport

NIF3L1 BP1 (Y-13) - sc-103072 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-THOC7 Antibody (C-Terminus) - LS-C345616 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of THOC7 Antibody with human 721_B Whole Cell lysate.

Anti-THOC7 Antibody (C-Terminus) - LS-C169931 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

THOC7 Antibody - NBP1-82076 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: THOC7 Antibody [NBP1-82076] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

THOC7 Antibody - NBP2-20622 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: THOC7 Antibody [NBP2-20622] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 15% SDS PAGE gel, diluted at 1:1000.

Anti-THOC7 antibody produced in rabbit - HPA044143 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-THOC7: <B>Cat. No. HPA044143</B>: Immunohistochemical staining of human cerebral cortex shows moderate nuclear positivity in neuronal cells.

Anti-THOC7 antibody produced in rabbit - SAB2700630 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-THOC7: <B>Cat. No. SAB2700630</B>: Immunofluorescence analysis of paraformaldehyde-fixed A431, using THOC7 antibody at 1:500 dilution.

THOC7 Antibody - C-terminal region (ARP67323_P050) - ARP67323_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

THOC7 Antibody - C-terminal region (ARP67324_P050) - ARP67324_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

THOC7-Antibody-C-term - AP9905b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of THOC7 Antibody (C-term) (Cat. #AP9905b) in mouse spleen tissue lysates (35ug/lane). THOC7 (arrow) was detected using the purified Pab.

THOC7 antibody - 70R-20812 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

THOC7 Antibody - abx034566 from Abbexa

Host Rabbit
Clonality Polyclonal

THOC7 antibody - 17881-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human kidney using 17881-1-AP(THOC7 antibody) at dilution of 1:100 (under 40x lens)

Rabbit Anti-THOC7 (C-term) - 102-18441 from RayBiotech

Host Rabbit
Western blot analysis of THOC7 Antibody (C-term) (Cat# 102-18441) in mouse spleen tissue lysates (35ug/lane). THOC7 (arrow) was detected using the purified Pab.

THOC7 antibody - 17881-1-AP from Proteintech Group

Prices $279.00
Sizes con: 22 μg/150μl
Host Rabbit
Clonality Polyclonal
mouse testis tissue were subjected to SDS PAGE followed by western blot with 17881-1-AP(THOC7 antibody) at dilution of 1:800

THOC7 Antibody - 36221 from Signalway Antibody

Prices $279.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Gel: 10%SDS-PAGE Lysates (from left to right): Mouse spleen and human fetal liver tissue, hela cell and mouse testis tissue, A431 cell Amount of lysate: 40ug per lane Primary antibody: 1/500 dilution Secondary antibody dilution: 1/8000 Exposure time: 15 seconds

THOC7 Polyclonal Antibody - ESAP11104 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Mouse spleen and human fetal liver tissue, hela cell and mouse testis tissue, A431 cell, using THOC7 Polyclonal Antibody at dilution of 1:500

THOC7 Polyclonal Antibody - ESAP15019 from Elabscience

Prices $296.00, $485.00
Sizes 120 μl, 200 μl
Host Rabbit
Clonality Polyclonal
Western blot analysis of Mouse spleen and human fetal liver tissue, hela cell and human fetal brain tissue, using THOC7 Polyclonal Antibody at dilution of 1:450

Anti-THOC7 monoclonal antibody - DCABH-17103 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

Anti-THOC7 (aa 6-193) polyclonal antibody - DPABH-05000 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

THOC7 Polyclonal Antibody - PA5-31594 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of THOC7 in paraformaldehyde-fixed A431 cells using a THOC7 polyclonal antibody (Product # PA5-31594) at a 1:200 dilution.

THO complex 7 homolog, Polyclonal Antibody - MBS719241 from MyBioSource

Prices $230.00, $500.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal

THOC7, Polyclonal Antibody - MBS2520140 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

THOC7, Polyclonal Antibody - MBS2516593 from MyBioSource

Prices $110.00, $150.00, $225.00, $360.00
Sizes 20 µl, 60 µl, 120 µl, 200 µl
Host Rabbit
Clonality Polyclonal

THOC7 - MBS271050 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: 293T B: A431 12% SDS PAGE diluted at 1:1000
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