THOC7

Gene Symbol	THOC7
Entrez Gene	80145
Alt Symbol	NIF3L1BP1, fSAP24, hTREX30
Species	Human
Gene Type	protein-coding
Description	THO complex 7
Other Description	NIF3L1-binding protein 1|Ngg1 interacting factor 3 like 1 binding protein 1|THO complex 7 homolog|THO complex subunit 7 homolog|functional spliceosome-associated protein 24|ngg1-interacting factor 3-like protein 1-binding protein 1
Swissprots	Q9H5H0 Q8WUF2 Q6P1L3 Q6I9Y2
Accessions	EAW65418 EAW65419 EAW65420 EAW65421 Q6I9Y2 AF104914 AI391685 AI784549 AK027098 BAB15656 AK225110 BC020599 AAH20599 BC065012 AAH65012 BI914906 CR457373 CAG33654 HQ448116 ADQ32597 HY023143 XM_006713339 XP_006713402 NM_001285387 NP_001272316 NM_001285404 NP_001272333 NM_025075 NP_079351
Function	Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23222130}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human THOC7 full length protein - ab164203 from Abcam Category Protein Source Wheat germ Species Human

Human THOC7 full length protein - ab202166 from Abcam Category Protein Source E. coli Species Human

THOC7 Antibody Blocking Peptide - LS-E24387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

THOC7 Recombinant Protein - H00080145-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

THOC7 protein (His tag) - 80R-4077 from Fitzgerald Category Protein Prices $375.00 Sizes 50 µg Source E.coli

THOC7 (1-204, His-tag) - AR51763PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

THOC7 (1-204, His-tag) - AR51763PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

THOC7 - H00080145-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

THOC7 - H00080145-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

THOC7 fusion protein - Ag12024 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

THOC7 fusion protein - Ag11795 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human THO complex subunit 7 homolog(THOC7) - CSB-YP746911HU CSB-EP746911HU CSB-BP746911HU CSB-MP746911HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

THOC7, 1-204aa, Human, His tag, E.coli - ATGP2943 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

THOC7 - TP309500 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

THO complex subunit 7 homolog (thoc7), Recombinant Protein - MBS1109571 from MyBioSource Category Protein Prices $955.00, $955.00, $1,180.00, $1,180.00, $1,425.00, $1,425.00, $1,890.00, $1,890.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

THO complex subunit 7 homolog (THOC7), Recombinant Protein - MBS1470606 from MyBioSource Category Protein Prices $950.00, $950.00, $1,175.00, $1,175.00, $1,425.00, $1,425.00, $1,885.00, $1,885.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

THOC7, Recombinant Protein - MBS205824 from MyBioSource Category Protein Prices $375.00, $925.00 Sizes 50 µg, 250 µg Source E Coli Species Human

THOC7 Recombinant Protein Antigen - NBP1-82076PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

THOC7-Antibody-C-term-Blocking-Peptide - BP9905b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

THOC7 Peptide, Human - M34GP15918H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human THOC7 Protein - NBP2-51950 from Novus Biologicals Category Protein Prices $339.00, $1,009.00 Sizes 50 µg, 250 µg Source E. coli Species Human

THOC7 - PAT-83088-1 from Nordic BioSite Category Protein Species Human

THOC7 - PAT-83088-2 from Nordic BioSite Category Protein Species Human

THO Complex 7, Human Recombinant - 228-22270-1 from RayBiotech Category Protein Species Human

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