| Gene Symbol | THOC7 |
|---|---|
| Entrez Gene | 80145 |
| Alt Symbol | NIF3L1BP1, fSAP24, hTREX30 |
| Species | Human |
| Gene Type | protein-coding |
| Description | THO complex 7 |
| Other Description | NIF3L1-binding protein 1|Ngg1 interacting factor 3 like 1 binding protein 1|THO complex 7 homolog|THO complex subunit 7 homolog|functional spliceosome-associated protein 24|ngg1-interacting factor 3-like protein 1-binding protein 1 |
| Swissprots | Q9H5H0 Q8WUF2 Q6P1L3 Q6I9Y2 |
| Accessions | EAW65418 EAW65419 EAW65420 EAW65421 Q6I9Y2 AF104914 AI391685 AI784549 AK027098 BAB15656 AK225110 BC020599 AAH20599 BC065012 AAH65012 BI914906 CR457373 CAG33654 HQ448116 ADQ32597 HY023143 XM_006713339 XP_006713402 NM_001285387 NP_001272316 NM_001285404 NP_001272333 NM_025075 NP_079351 |
| Function | Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:18974867, ECO:0000269|PubMed:23222130}. |
| Subcellular Location | Cytoplasm. Nucleus. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization. |
| Top Pathways | RNA transport |
NIF3L1 BP1 CRISPR/Cas9 KO Plasmid (h) - sc-407559 from Santa Cruz Biotechnology
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NIF3L1 BP1 HDR Plasmid (h) - sc-407559-HDR from Santa Cruz Biotechnology
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NIF3L1 BP1 Double Nickase Plasmid (h) - sc-407559-NIC from Santa Cruz Biotechnology
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NIF3L1 BP1 Double Nickase Plasmid (h2) - sc-407559-NIC-2 from Santa Cruz Biotechnology
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NIF3L1 BP1 CRISPR Activation Plasmid (h) - sc-407559-ACT from Santa Cruz Biotechnology
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NIF3L1 BP1 CRISPR Activation Plasmid (h2) - sc-407559-ACT-2 from Santa Cruz Biotechnology
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NIF3L1 BP1 Lentiviral Activation Particles (h) - sc-407559-LAC from Santa Cruz Biotechnology
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NIF3L1 BP1 Lentiviral Activation Particles (h2) - sc-407559-LAC-2 from Santa Cruz Biotechnology
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NIF3L1 BP1 siRNA (h) - sc-78282 from Santa Cruz Biotechnology
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NIF3L1 BP1 shRNA Plasmid (h) - sc-78282-SH from Santa Cruz Biotechnology
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NIF3L1 BP1 shRNA (h) Lentiviral Particles - sc-78282-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02499 from Sigma-Aldrich
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THOC7 siRNA (Human) - CRJ2770 from Cohesion Biosciences
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THOC7 - MBS8219524 from MyBioSource
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shRNA set against Human THOC7 (NM_025075.2) - SHH426976 from Creative biogene
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shRNA set against Human THOC7(NM_025075.2) - SHL069492 from Creative biogene
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Human THOC7 siRNA - orb273271 from Biorbyt
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THOC7 shRNA Plasmid (Human) - CHJ2770 from Cohesion Biosciences
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THOC7 miRNA 3'UTR clone - MiUTR1H-10385 from Creative biogene
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