HSPB1

Gene Symbol	HSPB1
Entrez Gene	3315
Alt Symbol	CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27
Species	Human
Gene Type	protein-coding
Description	heat shock 27kDa protein 1
Other Description	28 kDa heat shock protein|HSP 27|epididymis secretory protein Li 102|estrogen-regulated 24 kDa protein|heat shock 27 kDa protein|heat shock 27kD protein 1|heat shock protein beta-1|stress-responsive protein 27
Swissprots	Q6FI47 Q96EI7 Q9UC35 Q96C20 B2R4N8 Q9UC36 Q9UC31 P04792 Q9UC34
Accessions	AAA62175 ABC88475 CDM22284 EAW71803 P04792 AB020027 BAB17232 AF086135 AK296890 BAG59449 AK311446 AK311894 BAG34835 AL050380 BC000510 AAH00510 BC012292 AAH12292 BC012768 AAH12768 BC014920 AAH14920 BC073768 AAH73768 BP231480 BT019888 AAV38691 CR407614 CAG28542 CR536489 CAG38728 DQ891304 ABM82230 DQ893349 ABM84275 DQ894489 ABM85415 DQ896669 ABM87668 FJ224323 ACI46015 S74571 AAB20722 U90906 AAB51056 X16477 CAA34498 X54079 CAA38016 NM_001540 NP_001531
Function	Involved in stress resistance and actin organization.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Tissue Specificity	Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. {ECO:0000269|PubMed:1560006}.
Top Pathways	VEGF signaling pathway, MAPK signaling pathway, Amoebiasis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® HSP27 siRNA I - 6356 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

SignalSilence ® HSP27 siRNA II - 6526 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

HSP 27 CRISPR/Cas9 KO Plasmid (h) - sc-400285 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 HDR Plasmid (h) - sc-400285-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 Double Nickase Plasmid (h) - sc-400285-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 Double Nickase Plasmid (h2) - sc-400285-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 CRISPR Activation Plasmid (h) - sc-400285-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 CRISPR Activation Plasmid (h2) - sc-400285-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 Lentiviral Activation Particles (h) - sc-400285-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 Lentiviral Activation Particles (h2) - sc-400285-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 siRNA (h) - sc-29350 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HSP 27 shRNA Plasmid (h) - sc-29350-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HSP 27 shRNA (h) Lentiviral Particles - sc-29350-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HSP 27 siRNA (h2) - sc-44264 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HSP 27 shRNA Plasmid (h2) - sc-44264-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HSP 27 shRNA (h2) Lentiviral Particles - sc-44264-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU112501 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1538 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1538 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

HSPB1 siRNA (Human) - CRH2267 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HSP27 RNAi - H00003315-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HSPB1 - MBS8240118 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HSP 27 CRISPR/Cas9 KO Plasmid (h2) - sc-400285-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HSP 27 HDR Plasmid (h2) - sc-400285-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HSPB1 shRNA Plasmid (Human) - CHH2267 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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