| Gene Symbol |
RANBP3
|
| Entrez Gene |
8498
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAN binding protein 3
|
| Other Description |
RAN-binding protein-3|ran-binding protein 3
|
| Swissprots |
Q9UG74 Q9BT47 O75759 O60405 Q9H6Z4 B2RAT8 O75760
|
| Accessions |
AAC14485 EAW69120 EAW69121 EAW69122 EAW69123 EAW69124 Q9H6Z4 AK025300 BAB15106 AK125183 AK222813 AK222990 BAD96710 AK299260 BAH12980 AK299856 BAH13150 AK301942 BAH13589 AK308205 AK314343 BAG36985 AL050149 CAB43293 BC004349 AAH04349 BM786367 CB306615 DQ234346 ABB29975 Y08697 CAA69956 Y08698 CAA69957 Y08699 CAA69958 XM_006722928 XP_006722991 XM_006722929 XP_006722992 XM_011528391 XP_011526693 XM_011528392 XP_011526694 XM_011528393 XP_011526695 XM_011528394 XP_011526696 NM_003624 NP_003615 NM_007320 NP_015559 NM_007322 NP_015561 NM_007321 NM_001300865 NP_001287794
|
| Function |
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19289081}. Nucleus {ECO:0000269|PubMed:19289081}.
|
| Tissue Specificity |
Widely expressed with high levels in testis and heart. {ECO:0000269|PubMed:9637251}.
|
| Top Pathways |
HTLV-I infection
|
