RANBP3

Gene Symbol	RANBP3
Entrez Gene	8498
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	RAN binding protein 3
Other Description	RAN-binding protein-3|ran-binding protein 3
Swissprots	Q9UG74 Q9BT47 O75759 O60405 Q9H6Z4 B2RAT8 O75760
Accessions	AAC14485 EAW69120 EAW69121 EAW69122 EAW69123 EAW69124 Q9H6Z4 AK025300 BAB15106 AK125183 AK222813 AK222990 BAD96710 AK299260 BAH12980 AK299856 BAH13150 AK301942 BAH13589 AK308205 AK314343 BAG36985 AL050149 CAB43293 BC004349 AAH04349 BM786367 CB306615 DQ234346 ABB29975 Y08697 CAA69956 Y08698 CAA69957 Y08699 CAA69958 XM_006722928 XP_006722991 XM_006722929 XP_006722992 XM_011528391 XP_011526693 XM_011528392 XP_011526694 XM_011528393 XP_011526695 XM_011528394 XP_011526696 NM_003624 NP_003615 NM_007320 NP_015559 NM_007322 NP_015561 NM_007321 NM_001300865 NP_001287794
Function	Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF- beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19289081}. Nucleus {ECO:0000269|PubMed:19289081}.
Tissue Specificity	Widely expressed with high levels in testis and heart. {ECO:0000269|PubMed:9637251}.
Top Pathways	HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RanBP3 full length protein - ab131887 from Abcam Category Protein Source Wheat germ Species Human

Human RanBP3 protein fragment - ab160055 from Abcam Category Protein Source Wheat germ Species Human

Human RanBP3 protein fragment - ab181938 from Abcam Category Protein Source E. coli Species Human

RanBP3 peptide - ab4940 from Abcam Category Peptide

RANBP3 Antibody Blocking Peptide - LS-E4129 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RANBP3 Antibody Blocking Peptide - LS-E21413 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RanBP3 Partial Recombinant Protein - H00008498-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RanBP3 Recombinant Protein - H00008498-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RANBP3-Antibody-N-term-Blocking-Peptide - BP16369a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RanBP3 Blocking Peptide - 33R-5623 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RANBP3 protein (His tag) - 80R-3847 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

RANBP3 (235-445, His-tag) - AR51534PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RANBP3 (235-445, His-tag) - AR51534PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RANBP3 - H00008498-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RANBP3 - H00008498-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RANBP3 - H00008498-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RANBP3 - H00008498-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RANBP3 Control Peptide - SP5156CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

RANBP3, 235-445aa, Human, His tag, E.coli - 01-P2714 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RANBP3 fusion protein - ag0155 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RANBP3, His-tagged - RANBP3-221H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ran-binding protein 3(RANBP3) - CSB-YP867162HU CSB-EP867162HU CSB-BP867162HU CSB-MP867162HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RANBP3, 235-445aa, Human, His tag, E.coli - ATGP2714 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RanBP3 Protein - abx165198 from Abbexa Category Protein Species Human, Mouse

RANBP3 (transcript variant RANBP3-d) - TP314493 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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