Gene Symbol | CSRP3 |
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Entrez Gene | 8048 |
Alt Symbol | CLP, CMD1M, CMH12, CRP3, LMO4, MLP |
Species | Human |
Gene Type | protein-coding |
Description | cysteine and glycine-rich protein 3 (cardiac LIM protein) |
Other Description | LIM domain only 4|cardiac LIM domain protein|cysteine and glycine-rich protein 3|muscle lim protein isoform |
Swissprots | Q9P131 P50461 |
Accessions | AAD00189 ABN05285 CAC60376 EAW68355 EAW68356 P50461 AA192614 AF121260 AAF28868 AI184002 AJ711422 AK313289 BAG36097 BC005900 AAH05900 BC024010 AAH24010 BC057221 AAH57221 BF671742 DQ893125 ABM84051 DQ896402 ABM87401 JN898958 AFH66949 U20324 AAA91104 U49837 AAA92571 U72899 AAD00183 NM_003476 NP_003467 |
Function | Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250, ECO:0000305}. |
Tissue Specificity | Cardiac and slow-twitch skeletal muscles. |
CRP3 (B-4) - sc-393599 from Santa Cruz Biotechnology
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CRP3 (A-5) - sc-166930 from Santa Cruz Biotechnology
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CRP3 (H-46) - sc-98827 from Santa Cruz Biotechnology
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CRP3 (S-18) - sc-30275 from Santa Cruz Biotechnology
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CRP3 (G-16) - sc-30274 from Santa Cruz Biotechnology
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Anti-CSRP3 antibody - ab155538 from Abcam
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Anti-CSRP3 antibody - ab73142 from Abcam
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Anti-CSRP3 antibody - ab56368 from Abcam
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Anti-CSRP3 antibody - ab130638 from Abcam
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Anti-CSRP3 antibody [EPR12616(B)] - ab173301 from Abcam
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Anti-CSRP3 / MLP Antibody (Internal) IHC-plus™ - LS-B6484 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (C-Terminus) - LS-C144687 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, APC) - LS-C255573 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, AP) - LS-C255571 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, Biotin) - LS-C255574 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa75-124) - LS-C30595 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa75-124) - LS-C29981 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (C-Terminus) - LS-C29932 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, Azide-free, HRP) - LS-C255577 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, PE) - LS-C255579 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120, FITC) - LS-C255576 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120) - LS-C329433 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (aa90-120) - LS-C167099 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody - LS-C334803 from LifeSpan Bioscience
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Anti-CSRP3 / MLP Antibody (clone 6D2) - LS-C198524 from LifeSpan Bioscience
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