Gene Symbol | CSRP3 |
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Entrez Gene | 8048 |
Alt Symbol | CLP, CMD1M, CMH12, CRP3, LMO4, MLP |
Species | Human |
Gene Type | protein-coding |
Description | cysteine and glycine-rich protein 3 (cardiac LIM protein) |
Other Description | LIM domain only 4|cardiac LIM domain protein|cysteine and glycine-rich protein 3|muscle lim protein isoform |
Swissprots | Q9P131 P50461 |
Accessions | AAD00189 ABN05285 CAC60376 EAW68355 EAW68356 P50461 AA192614 AF121260 AAF28868 AI184002 AJ711422 AK313289 BAG36097 BC005900 AAH05900 BC024010 AAH24010 BC057221 AAH57221 BF671742 DQ893125 ABM84051 DQ896402 ABM87401 JN898958 AFH66949 U20324 AAA91104 U49837 AAA92571 U72899 AAD00183 NM_003476 NP_003467 |
Function | Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18505755}. Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250, ECO:0000305}. |
Tissue Specificity | Cardiac and slow-twitch skeletal muscles. |
CRP3 CRISPR/Cas9 KO Plasmid (h) - sc-402025 from Santa Cruz Biotechnology
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CRP3 HDR Plasmid (h) - sc-402025-HDR from Santa Cruz Biotechnology
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CRP3 Double Nickase Plasmid (h) - sc-402025-NIC from Santa Cruz Biotechnology
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CRP3 Double Nickase Plasmid (h2) - sc-402025-NIC-2 from Santa Cruz Biotechnology
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CRP3 CRISPR Activation Plasmid (h) - sc-402025-ACT from Santa Cruz Biotechnology
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CRP3 CRISPR Activation Plasmid (h2) - sc-402025-ACT-2 from Santa Cruz Biotechnology
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CRP3 Lentiviral Activation Particles (h) - sc-402025-LAC from Santa Cruz Biotechnology
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CRP3 Lentiviral Activation Particles (h2) - sc-402025-LAC-2 from Santa Cruz Biotechnology
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CRP3 siRNA (h) - sc-106928 from Santa Cruz Biotechnology
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CRP3 shRNA Plasmid (h) - sc-106928-SH from Santa Cruz Biotechnology
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CRP3 shRNA (h) Lentiviral Particles - sc-106928-V from Santa Cruz Biotechnology
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CSRP3 RNAi - H00008048-R01V from Novus Biologicals
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MISSION® esiRNA - EHU143361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6668 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6668 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05645 from Sigma-Aldrich
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CSRP3 siRNA (Human) - CRH5352 from Cohesion Biosciences
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CSRP3 RNAi - H00008048-R01 from Novus Biologicals
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CSRP3 - MBS8225550 from MyBioSource
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shRNA set against Human CSRP3 (NM_003476.4) - SHH270681 from Creative biogene
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Human CSRP3 siRNA - orb265854 from Biorbyt
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CSRP3 shRNA Plasmid (Human) - CHH5352 from Cohesion Biosciences
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CSRP3 miRNA 3'UTR clone - MiUTR3H-03659 from Creative biogene
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