| Gene Symbol |
FBXL7
|
| Entrez Gene |
23194
|
| Alt Symbol |
FBL6, FBL7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 7
|
| Other Description |
F-box protein Fbl7|F-box/LRR-repeat protein 7
|
| Swissprots |
O94926 B9EGF1 D6RDY7 Q9UJT9
|
| Accessions |
CAJ42767 EAX08028 EAX08029 Q9UJT9 AB020647 BAA74863 AF174593 AAF04514 AF199356 AAF09248 AK021671 AK309585 AY425960 AAR07953 BC050571 BC075061 AAH75061 BC136424 AAI36425 BU633031 XM_005248273 XP_005248330 XM_011513998 XP_011512300 NM_001278317 NP_001265246 NM_012304 NP_036436
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.
|