Gene Symbol | FBXL7 |
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Entrez Gene | 23194 |
Alt Symbol | FBL6, FBL7 |
Species | Human |
Gene Type | protein-coding |
Description | F-box and leucine-rich repeat protein 7 |
Other Description | F-box protein Fbl7|F-box/LRR-repeat protein 7 |
Swissprots | O94926 B9EGF1 D6RDY7 Q9UJT9 |
Accessions | CAJ42767 EAX08028 EAX08029 Q9UJT9 AB020647 BAA74863 AF174593 AAF04514 AF199356 AAF09248 AK021671 AK309585 AY425960 AAR07953 BC050571 BC075061 AAH75061 BC136424 AAI36425 BU633031 XM_005248273 XP_005248330 XM_011513998 XP_011512300 NM_001278317 NP_001265246 NM_012304 NP_036436 |
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}. |
FBL7 CRISPR/Cas9 KO Plasmid (h) - sc-405043 from Santa Cruz Biotechnology
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FBL7 HDR Plasmid (h) - sc-405043-HDR from Santa Cruz Biotechnology
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FBL7 Double Nickase Plasmid (h) - sc-405043-NIC from Santa Cruz Biotechnology
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FBL7 Double Nickase Plasmid (h2) - sc-405043-NIC-2 from Santa Cruz Biotechnology
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FBL7 CRISPR Activation Plasmid (h) - sc-405043-ACT from Santa Cruz Biotechnology
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FBL7 CRISPR Activation Plasmid (h2) - sc-405043-ACT-2 from Santa Cruz Biotechnology
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FBL7 Lentiviral Activation Particles (h) - sc-405043-LAC from Santa Cruz Biotechnology
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FBL7 Lentiviral Activation Particles (h2) - sc-405043-LAC-2 from Santa Cruz Biotechnology
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FBL7 siRNA (h) - sc-62306 from Santa Cruz Biotechnology
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FBL7 shRNA Plasmid (h) - sc-62306-SH from Santa Cruz Biotechnology
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FBL7 shRNA (h) Lentiviral Particles - sc-62306-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU039451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8530 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8530 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11650 from Sigma-Aldrich
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FBXL7 siRNA (Human) - CRH8074 from Cohesion Biosciences
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FBXL7 RNAi - H00023194-R01 from Novus Biologicals
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FBXL7 - MBS8206698 from MyBioSource
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shRNA set against Human FBXL7 (NM_012304.3) - SHH293001 from Creative biogene
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shRNA set against Human FBXL7(NM_012304.3) - SHH051455 from Creative biogene
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Human FBXL7 siRNA - orb268576 from Biorbyt
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FBXL7 shRNA Plasmid (Human) - CHH8074 from Cohesion Biosciences
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FBXL7 miRNA 3'UTR clone - MiUTR1H-03543 from Creative biogene
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