Gene Symbol | BPHL |
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Entrez Gene | 670 |
Alt Symbol | BPH-RP, MCNAA, VACVASE |
Species | Human |
Gene Type | protein-coding |
Description | biphenyl hydrolase-like (serine hydrolase) |
Other Description | biphenyl hydrolase-related protein|breast epithelial mucin-associated antigen|valacyclovir hydrolase|valacyclovirase |
Swissprots | Q3KP51 Q13855 Q86WA6 Q00306 |
Accessions | EAW55119 EAW55120 EAW55121 EAW55122 EAW55123 Q86WA6 AJ617684 CAE85120 AK297518 BAG59925 AK314909 BAG37421 AL832502 BC037778 AAH37778 BC106901 AAI06902 BM977067 DC352501 X57653 CAA40859 X81372 CAA57137 NM_001302777 NP_001289706 NM_004332 NP_004323 NR_026648 NR_026649 |
Function | Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269|PubMed:18256025}. |
Tissue Specificity | Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269|PubMed:7759552}. |
VACVase (E-3) - sc-514189 from Santa Cruz Biotechnology
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VACVase (H-73) - sc-366824 from Santa Cruz Biotechnology
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VACVase (P-19) - sc-54454 from Santa Cruz Biotechnology
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Anti-BPHL antibody - ab72851 from Abcam
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Anti-BPHL antibody - ab173910 from Abcam
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Anti-BPHL antibody - ab123003 from Abcam
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Anti-MCNAA / BPHL Antibody (aa96-124, PE) - LS-C252655 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124, AP) - LS-C252978 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124, APC) - LS-C252979 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124, Biotin) - LS-C252980 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124, FITC) - LS-C252981 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124, Azide-free, HRP) - LS-C252982 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa34-83) - LS-C145937 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa95-124) - LS-C319864 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody - LS-C306560 from LifeSpan Bioscience
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Anti-MCNAA / BPHL Antibody (aa96-124) - LS-C159180 from LifeSpan Bioscience
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ATPB Antibody (4E5) - NBP2-02249 from Novus Biologicals
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BPHL Antibody - NBP2-38328 from Novus Biologicals
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BPHL Antibody - NBP1-88373 from Novus Biologicals
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BPHL Antibody - H00000670-B01 from Novus Biologicals
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Anti-BPHL antibody produced in mouse - SAB1400026 from Sigma-Aldrich
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BPHL antibody - N-terminal region (ARP61857_P050) - ARP61857_P050 from Aviva Systems Biology
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BPHL-Antibody-Center - AP18229c from Abgent, a WuXi AppTec company
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BPHL antibody [N1C3] - GTX105864 from GeneTex
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BPHL Antibody - middle region (OAAB13742) - OAAB13742 from Aviva Systems Biology
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