| Gene Symbol |
BPHL
|
| Entrez Gene |
670
|
| Alt Symbol |
BPH-RP, MCNAA, VACVASE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
biphenyl hydrolase-like (serine hydrolase)
|
| Other Description |
biphenyl hydrolase-related protein|breast epithelial mucin-associated antigen|valacyclovir hydrolase|valacyclovirase
|
| Swissprots |
Q3KP51 Q13855 Q86WA6 Q00306
|
| Accessions |
EAW55119 EAW55120 EAW55121 EAW55122 EAW55123 Q86WA6 AJ617684 CAE85120 AK297518 BAG59925 AK314909 BAG37421 AL832502 BC037778 AAH37778 BC106901 AAI06902 BM977067 DC352501 X57653 CAA40859 X81372 CAA57137 NM_001302777 NP_001289706 NM_004332 NP_004323 NR_026648 NR_026649
|
| Function |
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269|PubMed:18256025}.
|
| Tissue Specificity |
Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269|PubMed:7759552}.
|