Gene Symbol | BPHL |
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Entrez Gene | 670 |
Alt Symbol | BPH-RP, MCNAA, VACVASE |
Species | Human |
Gene Type | protein-coding |
Description | biphenyl hydrolase-like (serine hydrolase) |
Other Description | biphenyl hydrolase-related protein|breast epithelial mucin-associated antigen|valacyclovir hydrolase|valacyclovirase |
Swissprots | Q3KP51 Q13855 Q86WA6 Q00306 |
Accessions | EAW55119 EAW55120 EAW55121 EAW55122 EAW55123 Q86WA6 AJ617684 CAE85120 AK297518 BAG59925 AK314909 BAG37421 AL832502 BC037778 AAH37778 BC106901 AAI06902 BM977067 DC352501 X57653 CAA40859 X81372 CAA57137 NM_001302777 NP_001289706 NM_004332 NP_004323 NR_026648 NR_026649 |
Function | Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269|PubMed:18256025}. |
Tissue Specificity | Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269|PubMed:7759552}. |
VACVase CRISPR/Cas9 KO Plasmid (h) - sc-410706 from Santa Cruz Biotechnology
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VACVase HDR Plasmid (h) - sc-410706-HDR from Santa Cruz Biotechnology
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VACVase Double Nickase Plasmid (h) - sc-410706-NIC from Santa Cruz Biotechnology
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VACVase Double Nickase Plasmid (h2) - sc-410706-NIC-2 from Santa Cruz Biotechnology
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VACVase CRISPR Activation Plasmid (h) - sc-410706-ACT from Santa Cruz Biotechnology
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VACVase CRISPR Activation Plasmid (h2) - sc-410706-ACT-2 from Santa Cruz Biotechnology
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VACVase Lentiviral Activation Particles (h) - sc-410706-LAC from Santa Cruz Biotechnology
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VACVase Lentiviral Activation Particles (h2) - sc-410706-LAC-2 from Santa Cruz Biotechnology
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VACVase siRNA (h) - sc-106687 from Santa Cruz Biotechnology
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VACVase shRNA Plasmid (h) - sc-106687-SH from Santa Cruz Biotechnology
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VACVase shRNA (h) Lentiviral Particles - sc-106687-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4036 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4036 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04486 from Sigma-Aldrich
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BPHL siRNA (Human) - CRH0465 from Cohesion Biosciences
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BPHL RNAi - H00000670-R01 from Novus Biologicals
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BPHL - MBS8207507 from MyBioSource
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shRNA set against Human BPHL (NM_004332.2) - SHH247434 from Creative biogene
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BPHL shRNA Plasmid (Human) - CHH0465 from Cohesion Biosciences
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BPHL miRNA 3'UTR clone - MiUTR3H-05724 from Creative biogene
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