POLR2M
| Gene Symbol | POLR2M |
|---|---|
| Entrez Gene | 81488 |
| Alt Symbol | GCOM1, GRINL1A, Gdown, Gdown1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) II (DNA directed) polypeptide M |
| Other Description | DNA-directed RNA polymerase II subunit M, isoforms 4/5|GRINL1A downstream protein Gdown4|glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A|protein GRINL1A|protein GRINL1A, isoforms 4/5 |
| Swissprots | Q6K051 Q6EF02 Q6EF46 Q8NC58 Q6EEV7 Q6EF00 Q6EFN8 Q9Y3V6 Q96NF5 Q6ZQZ3 Q6K046 Q6K050 Q6EER8 Q8NCF3 D2E9U7 Q96DI5 P0CAP1 Q6EM48 Q96JB7 Q6EEV4 P0CAP2 Q6EF01 Q6EEV3 Q6EES2 |
| Accessions | CAF86856 EAW77525 EAW77527 P0CAP2 Q6EEV4 AF086209 AF326773 AAK92284 AK074767 BAC11193 AK074955 BAC11313 AK128618 BAC87533 AK223571 BAD97291 AK308873 AL050091 CAB43263 AM392721 CAL37599 AY339380 AAQ82540 AY341344 AAQ76830 AY353061 AAQ76837 BC001510 AAH01510 BF939412 BI833260 BQ072611 DQ893035 ABM83961 DQ896276 ABM87275 NM_001018102 NP_001018112 NM_015532 NP_056347 NR_027390 |
| Function | Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cell junction {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:21240187}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected in heart, liver, skeletal muscle, placenta, small intestine, lung, prostate and testis. {ECO:0000269|PubMed:15233991, ECO:0000269|PubMed:20093627}. |
GRINL1A CRISPR/Cas9 KO Plasmid (h) - sc-410164 from Santa Cruz Biotechnology
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GRINL1A HDR Plasmid (h) - sc-410164-HDR from Santa Cruz Biotechnology
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GRINL1A Double Nickase Plasmid (h) - sc-410164-NIC from Santa Cruz Biotechnology
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GRINL1A Double Nickase Plasmid (h2) - sc-410164-NIC-2 from Santa Cruz Biotechnology
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GRINL1A CRISPR Activation Plasmid (h) - sc-410164-ACT from Santa Cruz Biotechnology
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GRINL1A CRISPR Activation Plasmid (h2) - sc-410164-ACT-2 from Santa Cruz Biotechnology
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GRINL1A Lentiviral Activation Particles (h) - sc-410164-LAC from Santa Cruz Biotechnology
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GRINL1A Lentiviral Activation Particles (h2) - sc-410164-LAC-2 from Santa Cruz Biotechnology
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GRINL1A siRNA (h) - sc-90166 from Santa Cruz Biotechnology
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GRINL1A shRNA Plasmid (h) - sc-90166-SH from Santa Cruz Biotechnology
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GRINL1A shRNA (h) Lentiviral Particles - sc-90166-V from Santa Cruz Biotechnology
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GRINL1A RNAi - H00081488-R04 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9692 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9692 from Sigma-Aldrich
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POLR2M siRNA (Human) - CRJ2972 from Cohesion Biosciences
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POLR2M siRNA (Human) - CRJ2973 from Cohesion Biosciences
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GRINL1A RNAi - H00081488-R06 from Novus Biologicals
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GRINL1A RNAi - H00081488-R05 from Novus Biologicals
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shRNA set against Human GRINL1A (NM_015532.3) - SHH307982 from Creative biogene
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Human POLR2M siRNA - orb273474 from Biorbyt
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POLR2M shRNA Plasmid (Human) - CHJ2972 from Cohesion Biosciences
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POLR2M shRNA Plasmid (Human) - CHJ2973 from Cohesion Biosciences
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POLR2M miRNA 3'UTR clone - MiUTR1H-04277 from Creative biogene
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