| Gene Symbol |
PRPF8
|
| Entrez Gene |
10594
|
| Alt Symbol |
HPRP8, PRP8, PRPC8, RP13, SNRNP220
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pre-mRNA processing factor 8
|
| Other Description |
220 kDa U5 snRNP-specific protein|PRP8 homolog|PRP8 pre-mRNA processing factor 8 homolog|U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p|apoptosis-regulated protein 1|apoptosis-regulated protein 2|p220|pre-mRNA-processing-splicing factor 8|precursor mRNA processing protein|splicing factor Prp8
|
| Swissprots |
Q6P2Q9 O75965 O14547
|
| Accessions |
EAW90588 EAW90589 EAW90590 EAW90591 EAW90592 EAW90593 EAW90594 Q6P2Q9 AB007510 BAA22563 AF092565 AAC61776 AK058034 AK126169 AK222905 BAD96625 AK296344 BAG59028 AY486134 AAS64747 AY486135 AAS64748 BC000579 BC034545 BC064370 AAH64370 BX649099 CD698473 DB081408 NM_006445 NP_006436
|
| Function |
Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:20595234, ECO:0000303|PubMed:15840809}.
|
| Subcellular Location |
Nucleus speckle {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:10411133}.
|
| Top Pathways |
Spliceosome
|