PRPF8

Gene Symbol PRPF8
Entrez Gene 10594
Alt Symbol HPRP8, PRP8, PRPC8, RP13, SNRNP220
Species Human
Gene Type protein-coding
Description pre-mRNA processing factor 8
Other Description 220 kDa U5 snRNP-specific protein|PRP8 homolog|PRP8 pre-mRNA processing factor 8 homolog|U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p|apoptosis-regulated protein 1|apoptosis-regulated protein 2|p220|pre-mRNA-processing-splicing factor 8|precursor mRNA processing protein|splicing factor Prp8
Swissprots Q6P2Q9 O75965 O14547
Accessions EAW90588 EAW90589 EAW90590 EAW90591 EAW90592 EAW90593 EAW90594 Q6P2Q9 AB007510 BAA22563 AF092565 AAC61776 AK058034 AK126169 AK222905 BAD96625 AK296344 BAG59028 AY486134 AAS64747 AY486135 AAS64748 BC000579 BC034545 BC064370 AAH64370 BX649099 CD698473 DB081408 NM_006445 NP_006436
Function Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. {ECO:0000269|PubMed:20595234, ECO:0000303|PubMed:15840809}.
Subcellular Location Nucleus speckle {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10411133}.
Top Pathways Spliceosome

PRP8 CRISPR/Cas9 KO Plasmid (h) - sc-402819 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 HDR Plasmid (h) - sc-402819-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 Double Nickase Plasmid (h) - sc-402819-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 Double Nickase Plasmid (h2) - sc-402819-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 CRISPR Activation Plasmid (h) - sc-402819-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 CRISPR Activation Plasmid (h2) - sc-402819-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 Lentiviral Activation Particles (h) - sc-402819-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 Lentiviral Activation Particles (h2) - sc-402819-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 siRNA (h) - sc-38209 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRP8 shRNA Plasmid (h) - sc-38209-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRP8 shRNA (h) Lentiviral Particles - sc-38209-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PRPF8 RNAi - H00010594-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU087301 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17481 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17481 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01341 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01341

PRPF8 siRNA (Human) - CRH7211 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRP8 CRISPR/Cas9 KO Plasmid (h2) - sc-402819-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PRP8 HDR Plasmid (h2) - sc-402819-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human PRPF8 (NM_006445.3) - SHH383832 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PRPF8(NM_006445.3) - SHR142862 from Creative biogene

Category siRNA
Species Reactivities Human

PRPF8 shRNA Plasmid (Human) - CHH7211 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRPF8 miRNA 3'UTR clone - MiUTR1H-08320 from Creative biogene

Species Reactivities Human
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