Gene Symbol | SLC17A7 |
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Entrez Gene | 57030 |
Alt Symbol | BNPI, VGLUT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 17 (vesicular glutamate transporter), member 7 |
Other Description | brain-specific Na(+)-dependent inorganic phosphate cotransporter|brain-specific Na-dependent inorganic phosphate cotransporter|solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7|solute carrier family 17 member 7|vesicular glutamate transporter 1 |
Swissprots | Q6PCD0 Q9P2U7 B4DG46 B4DFR9 |
Accessions | EAW52485 Q9P2U7 AB032436 BAA92875 AK057879 AK091061 AK095659 AK289622 BAF82311 AK294226 BAG57530 AK294405 BAG57657 BC059379 AAH59379 BG701511 BQ636968 BU732143 NM_020309 NP_064705 |
Function | Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226}. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}. |
Tissue Specificity | Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe. {ECO:0000269|PubMed:10820226}. |
Top Pathways | Synaptic vesicle cycle, Glutamatergic synapse, Nicotine addiction, Retrograde endocannabinoid signaling |
BNPI CRISPR/Cas9 KO Plasmid (h) - sc-403333 from Santa Cruz Biotechnology
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BNPI HDR Plasmid (h) - sc-403333-HDR from Santa Cruz Biotechnology
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BNPI Double Nickase Plasmid (h) - sc-403333-NIC from Santa Cruz Biotechnology
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BNPI Double Nickase Plasmid (h2) - sc-403333-NIC-2 from Santa Cruz Biotechnology
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BNPI CRISPR Activation Plasmid (h) - sc-403333-ACT from Santa Cruz Biotechnology
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BNPI CRISPR Activation Plasmid (h2) - sc-403333-ACT-2 from Santa Cruz Biotechnology
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BNPI Lentiviral Activation Particles (h) - sc-403333-LAC from Santa Cruz Biotechnology
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BNPI Lentiviral Activation Particles (h2) - sc-403333-LAC-2 from Santa Cruz Biotechnology
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BNPI siRNA (h) - sc-29816 from Santa Cruz Biotechnology
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BNPI shRNA Plasmid (h) - sc-29816-SH from Santa Cruz Biotechnology
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BNPI shRNA (h) Lentiviral Particles - sc-29816-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU030481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19439 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19439 from Sigma-Aldrich
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SLC17A7 siRNA (Human) - CRJ1294 from Cohesion Biosciences
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VGLUT1 RNAi - H00057030-R01 from Novus Biologicals
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SLC17A7 - MBS8216936 from MyBioSource
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shRNA set against Human SLC17A7 (NM_020309.3) - SHH408788 from Creative biogene
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SLC17A7 shRNA Plasmid (Human) - CHJ1294 from Cohesion Biosciences
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SLC17A7 miRNA 3'UTR clone - MiUTR3H-07452 from Creative biogene
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