SUV420H1
| Gene Symbol | SUV420H1 |
|---|---|
| Entrez Gene | 51111 |
| Alt Symbol | CGI-85, CGI85, KMT5B |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of variegation 4-20 homolog 1 (Drosophila) |
| Other Description | C630029K18Rik|histone-lysine N-methyltransferase SUV420H1|lysine N-methyltransferase 5B|su(var)4-20 homolog 1|suv4-20h1 |
| Swissprots | Q4V775 Q9H022 Q4FZB7 Q9Y393 Q9BUL0 B7WNX7 Q9NXV3 Q3SX56 Q6P150 Q96E44 Q9H2K3 |
| Accessions | EAW74697 EAW74698 EAW74699 EAW74700 EAW74701 Q4FZB7 AF151843 AAD34080 AF264782 AAG36937 AI659791 AK000046 BAA90905 AK025183 AK025461 AK026428 AK225203 AK299201 BAH12968 AK314336 AL512763 CAC21680 BC002522 AAH02522 BC012933 AAH12933 BC065287 AAH65287 BC087834 AAH87834 BC098121 AAH98121 BC099714 AAH99714 BC103498 AAI03499 BC104483 AAI04484 BC108304 BG697990 BM152996 BM719058 CR997801 XM_005274035 XP_005274092 XM_005274036 XP_005274093 XM_005274037 XP_005274094 XM_006718581 XP_006718644 XM_011545091 XP_011543393 XM_011545092 XP_011543394 XM_011545093 XP_011543395 XM_011545094 XP_011543396 NM_001300907 NP_001287836 NM_001300908 NP_001287837 NM_001300909 NP_001287838 NM_016028 NP_057112 NM_017635 NP_060105 |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269|PubMed:23720823}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}. |
| Top Pathways | Lysine degradation |
SUV420H1 (N-15) - sc-169462 from Santa Cruz Biotechnology
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SUV420H1 (Q-23) - sc-134048 from Santa Cruz Biotechnology
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Anti-SUV420h1 antibody - ab104875 from Abcam
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Anti-SUV420h1 antibody - C-terminal - ab170784 from Abcam
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Anti-SUV420H1 Antibody (Internal) - LS-C144992 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY650) - LS-C181924 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (Biotin) - LS-C181923 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY488) - LS-C181925 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (HRP) - LS-C181926 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY550) - LS-C181927 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY650) - LS-C181929 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (Biotin) - LS-C181928 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY488) - LS-C181930 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (HRP) - LS-C181931 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa763-812) - LS-C31658 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (DY550) - LS-C181932 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797, APC) - LS-C270770 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797, AP) - LS-C270769 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797, FITC) - LS-C270771 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa763-812) - LS-C30063 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797, PE) - LS-C270772 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797) - LS-C325511 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (C-Terminus) - LS-C145703 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (C-Terminus) - LS-C109962 from LifeSpan Bioscience
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Anti-SUV420H1 Antibody (aa766-797) - LS-C161629 from LifeSpan Bioscience
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