SUV420H1

Gene Symbol	SUV420H1
Entrez Gene	51111
Alt Symbol	CGI-85, CGI85, KMT5B
Species	Human
Gene Type	protein-coding
Description	suppressor of variegation 4-20 homolog 1 (Drosophila)
Other Description	C630029K18Rik|histone-lysine N-methyltransferase SUV420H1|lysine N-methyltransferase 5B|su(var)4-20 homolog 1|suv4-20h1
Swissprots	Q4V775 Q9H022 Q4FZB7 Q9Y393 Q9BUL0 B7WNX7 Q9NXV3 Q3SX56 Q6P150 Q96E44 Q9H2K3
Accessions	EAW74697 EAW74698 EAW74699 EAW74700 EAW74701 Q4FZB7 AF151843 AAD34080 AF264782 AAG36937 AI659791 AK000046 BAA90905 AK025183 AK025461 AK026428 AK225203 AK299201 BAH12968 AK314336 AL512763 CAC21680 BC002522 AAH02522 BC012933 AAH12933 BC065287 AAH65287 BC087834 AAH87834 BC098121 AAH98121 BC099714 AAH99714 BC103498 AAI03499 BC104483 AAI04484 BC108304 BG697990 BM152996 BM719058 CR997801 XM_005274035 XP_005274092 XM_005274036 XP_005274093 XM_005274037 XP_005274094 XM_006718581 XP_006718644 XM_011545091 XP_011543393 XM_011545092 XP_011543394 XM_011545093 XP_011543395 XM_011545094 XP_011543396 NM_001300907 NP_001287836 NM_001300908 NP_001287837 NM_001300909 NP_001287838 NM_016028 NP_057112 NM_017635 NP_060105
Function	Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269|PubMed:23720823}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SUV420h1 protein fragment - ab80286 from Abcam Category Protein Source E. coli Species Human

SUV420H1 Antibody Blocking Peptide - LS-E1406 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV420H1 Antibody Blocking Peptide - LS-E12272 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV420H1 Antibody Blocking Peptide - LS-E12369 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUV420H1 Antibody Blocking Peptide - LS-E18448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SUV420h1 Protein - H00051111-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SUV4-20H1-Antibody-C-term-Blocking-peptide - BP12072b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV4-20H1-Antibody-N-term-Blocking-peptide - BP12877a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUV420H1 / KMT5B - H00051111-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SUV420H1 fusion protein - ag11194 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant SUV420H1 protein - 31360 from ActiveMotif Category Protein Prices $395.00 Sizes 50 µg Source E. coli Species Human

Recombinant Human SUV420H1, GST-tagged - SUV420H1-473H from Creative Biomart Category Protein Source E.Coli .

Recombinant Human SUV420H1 - SUV420H1-31486TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Histone-lysine N-methyltransferase SUV420H1(SUV420H1) ,partial - CSB-YP674569HU CSB-EP674569HU CSB-BP674569HU CSB-MP674569HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human SUV420H1 Protein, GST-tagged - SUV420H1-210H from Creative Biomart Category Protein Source Insect cell Species Human

Recombinant Human SUV420H1 Protein, GST-tagged - SUV420H1-211H from Creative Biomart Category Protein Source Insect cell Species Human

SUV420h1 Protein - NBP1-92461PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SUV420H1 Peptide, Human - M34GP15430H from Creative Peptides Category Peptide Source Synthetic. Species Human

SUV420h1 Recombinant Protein Antigen - NBP2-57721PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Histone-lysine N-methyltransferase SUV420H1 (SUV420H1), partial, Recombinant Protein - MBS1284881 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SUV420H1, Recombinant Protein - MBS515678 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

SUV420H1, Recombinant Protein - MBS515679 from MyBioSource Category Protein Prices $315.00, $425.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

Recombinant SUV420H1 (2-387) protein - 81021 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 50 µg, 1 mg Source E. coli Species Human

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