SUV420H1

Gene Symbol SUV420H1
Entrez Gene 51111
Alt Symbol CGI-85, CGI85, KMT5B
Species Human
Gene Type protein-coding
Description suppressor of variegation 4-20 homolog 1 (Drosophila)
Other Description C630029K18Rik|histone-lysine N-methyltransferase SUV420H1|lysine N-methyltransferase 5B|su(var)4-20 homolog 1|suv4-20h1
Swissprots Q4V775 Q9H022 Q4FZB7 Q9Y393 Q9BUL0 B7WNX7 Q9NXV3 Q3SX56 Q6P150 Q96E44 Q9H2K3
Accessions EAW74697 EAW74698 EAW74699 EAW74700 EAW74701 Q4FZB7 AF151843 AAD34080 AF264782 AAG36937 AI659791 AK000046 BAA90905 AK025183 AK025461 AK026428 AK225203 AK299201 BAH12968 AK314336 AL512763 CAC21680 BC002522 AAH02522 BC012933 AAH12933 BC065287 AAH65287 BC087834 AAH87834 BC098121 AAH98121 BC099714 AAH99714 BC103498 AAI03499 BC104483 AAI04484 BC108304 BG697990 BM152996 BM719058 CR997801 XM_005274035 XP_005274092 XM_005274036 XP_005274093 XM_005274037 XP_005274094 XM_006718581 XP_006718644 XM_011545091 XP_011543393 XM_011545092 XP_011543394 XM_011545093 XP_011543395 XM_011545094 XP_011543396 NM_001300907 NP_001287836 NM_001300908 NP_001287837 NM_001300909 NP_001287838 NM_016028 NP_057112 NM_017635 NP_060105
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269|PubMed:23720823}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Top Pathways Lysine degradation

SUV420H1 - MBS1265980 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC103498

SUV420H1 - MBS1265864 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC002522

Human SUV420H1 cDNA clone(NM_016028.4) - CDFG000022 from Creative Biomart

Species Human
Accession NM_016028.4

Human SUV420H1 cDNA clone(NM_017635.3) - CDFG000859 from Creative Biomart

Species Human
Accession NM_017635.3

human SUV420H1 ORF clone - CDCH087730 from Creative Biomart

Species Human
Accession NM_016028

human SUV420H1 ORF clone - CDCH087731 from Creative Biomart

Species Human
Accession NM_016028

human SUV420H1 ORF clone - CDCH087732 from Creative Biomart

Species Human
Accession NM_016028

human SUV420H1 ORF clone - CDCH087733 from Creative Biomart

Species Human
Accession NM_016028

human SUV420H1 ORF clone - CDCH087734 from Creative Biomart

Species Human
Accession NM_016028

human SUV420H1 ORF clone - CDCH087735 from Creative Biomart

Species Human
Accession NM_016028

Human SUV420H1 ORF Clone(NM_017635.3) - CDCL177582 from Creative Biomart

Species Human
Accession NM_017635.3

Human SUV420H1 ORF Clone(NM_016028.4) - CDCL177583 from Creative Biomart

Species Human
Accession NM_016028.4

Human SUV420H1 ORF Clone(NM_016028.4) - CDCL177584 from Creative Biomart

Species Human
Accession NM_016028.4

Human SUV420H1 ORF clone(NM_017635.3) - CDCL186365 from Creative Biomart

Species Human
Accession NM_017635.3

Human SUV420H1 ORF Clone(NM_016028.4) - CDCR300369 from Creative Biomart

Species Human
Accession NM_016028.4

Human SUV420H1 ORF Clone(NM_016028.4) - CDCR300370 from Creative Biomart

Species Human
Accession NM_016028.4

Human SUV420H1 ORF Clone(NM_017635.3) - CDCR302004 from Creative Biomart

Species Human
Accession NM_017635.3

Human SUV420H1 ORF Clone(NM_017635.3) - CDCR302005 from Creative Biomart

Species Human
Accession NM_017635.3

Human SUV420H1 ORF Clone(NM_017635.3) - CDCR302006 from Creative Biomart

Species Human
Accession NM_017635.3
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