Gene Symbol | CGN |
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Entrez Gene | 57530 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cingulin |
Other Description | - |
Swissprots | Q9P2M7 Q5T386 Q9NR25 A7MD22 A6H8L3 |
Accessions | EAW53434 EAW53435 Q9P2M7 AB037740 BAA92557 AF263462 AAF74498 AK290007 BAF82696 BC146657 AAI46658 BC150604 AAI50605 BC152445 AAI52446 BP331021 BX647343 CN359389 DQ656045 DQ656046 XM_005245365 XP_005245422 XR_921902 NM_020770 NP_065821 |
Function | Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. |
Subcellular Location | Cell junction, tight junction {ECO:0000250}. Note=Localizes to the apical junction complex composed of tight and adherens junctions. {ECO:0000250}. |
Tissue Specificity | Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. |
Top Pathways | Tight junction |
Cingulin CRISPR/Cas9 KO Plasmid (h) - sc-404409 from Santa Cruz Biotechnology
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Cingulin HDR Plasmid (h) - sc-404409-HDR from Santa Cruz Biotechnology
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Cingulin Double Nickase Plasmid (h) - sc-404409-NIC from Santa Cruz Biotechnology
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Cingulin Double Nickase Plasmid (h2) - sc-404409-NIC-2 from Santa Cruz Biotechnology
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Cingulin CRISPR Activation Plasmid (h) - sc-404409-ACT from Santa Cruz Biotechnology
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Cingulin CRISPR Activation Plasmid (h2) - sc-404409-ACT-2 from Santa Cruz Biotechnology
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Cingulin Lentiviral Activation Particles (h) - sc-404409-LAC from Santa Cruz Biotechnology
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Cingulin Lentiviral Activation Particles (h2) - sc-404409-LAC-2 from Santa Cruz Biotechnology
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Cingulin siRNA (h) - sc-45677 from Santa Cruz Biotechnology
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Cingulin shRNA Plasmid (h) - sc-45677-SH from Santa Cruz Biotechnology
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Cingulin shRNA (h) Lentiviral Particles - sc-45677-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6020 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6020 from Sigma-Aldrich
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CGN siRNA (Human) - CRJ1511 from Cohesion Biosciences
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CGN - MBS8238462 from MyBioSource
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Cingulin CRISPR/Cas9 KO Plasmid (h2) - sc-404409-KO-2 from Santa Cruz Biotechnology
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Cingulin HDR Plasmid (h2) - sc-404409-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CGN (NM_020770.2) - SHH262569 from Creative biogene
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Cingulin antibody - orb272012 from Biorbyt
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CGN shRNA Plasmid (Human) - CHJ1511 from Cohesion Biosciences
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CGN miRNA 3'UTR clone - MiUTR3H-10624 from Creative biogene
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