DDX42

Gene Symbol	DDX42
Entrez Gene	11325
Alt Symbol	DDX42P, RHELP, RNAHP, SF3B8, SF3b125
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 42
Other Description	ATP-dependent RNA helicase DDX42|DEAD (Asp-Glu-Ala-Asp) box polypeptide 42|SF3b DEAD box protein|splicing factor 3B-associated 125 kDa protein|splicing factor 3b, subunit 8
Swissprots	Q96HR7 Q9Y3V8 Q68G51 O75619 A8KA43 Q86XP3 Q96BK1 A6NML1
Accessions	EAW94276 EAW94277 EAW94278 Q86XP3 AB036090 BAC66466 AF083255 AAC32396 AF147429 AK001964 BAG50996 AK095772 BAG53126 AK096751 AK122737 BAG53696 AK126480 BAG54335 AK292908 BAF85597 AL050096 CAB43268 AL527653 AL545851 BC008208 AAH08208 BC015505 AAH15505 BC078667 AAH78667 BC093081 AAH93081 BK000566 DAA00077 DA440475 XM_006721657 XP_006721720 XM_011524259 XP_011522561 NM_007372 NP_031398 NM_203499 NP_987095
Function	ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.
Subcellular Location	Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.
Tissue Specificity	Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. {ECO:0000269|PubMed:10727850, ECO:0000269|PubMed:16397294}.
Top Pathways	Spliceosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DDX42 (K-15) - sc-132256 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

DDX42 (S-15) - sc-132257 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DDX42 antibody - ab89075 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DDX42 Antibody (aa800-850) - LS-C290036 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX42 Antibody - LS-C307861 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DDX42 Antibody (aa888-938) - LS-C290037 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX42 Antibody (C-Terminus) - LS-C345971 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DDX42 Antibody - NBP1-87135 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 Antibody - NBP1-87134 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 Antibody - NBP1-87133 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 Antibody - NBP1-57335 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

DDX42 Antibody - H00011325-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DDX42 antibody produced in rabbit - HPA023447 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX42 antibody produced in rabbit - AV36403 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DDX42 antibody produced in mouse - SAB1407136 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-DDX42 antibody produced in rabbit - HPA023571 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 antibody - N-terminal region (ARP36403_P050) - ARP36403_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 Antibody - C-terminal region (ARP73818_P050) - ARP73818_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

DDX42 antibody, N-term - GTX47520 from GeneTex Prices $319.00 Sizes 50 μg Host Rabbit Clonality Polyclonal

DDX42 antibody - 70R-4789 from Fitzgerald Prices $345.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti -DDX42 (ATP-dependent RNA Helicase DDX42, DEAD Box Protein 42, RNA Helicase-likeProtein, RHELP, RNA Helicase-related Protein, RNAHP, SF3b DEAD Box Protein, SplicingFactor 3B-associated 125 kDa Protein, SF3b125) - 125733 from USBiological Life Science Host Mouse Clonality Polyclonal

DDX42 antibody - H00011325-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

DDX42 Antibody - 28-490 from ProSci Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

DDX42 Antibody - GWB-MM377H from Genway Biotech Prices $404.00 Sizes 50 µg Clonality Polyclonal

DDX42 Antibody - A303-353A from Bethyl Labs Prices $99.00, $229.00, $339.00 Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (1 mg/ml) Host Rabbit Clonality Polyclonal

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