| Gene Symbol |
DDX42
|
| Entrez Gene |
11325
|
| Alt Symbol |
DDX42P, RHELP, RNAHP, SF3B8, SF3b125
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAD (Asp-Glu-Ala-Asp) box helicase 42
|
| Other Description |
ATP-dependent RNA helicase DDX42|DEAD (Asp-Glu-Ala-Asp) box polypeptide 42|SF3b DEAD box protein|splicing factor 3B-associated 125 kDa protein|splicing factor 3b, subunit 8
|
| Swissprots |
Q96HR7 Q9Y3V8 Q68G51 O75619 A8KA43 Q86XP3 Q96BK1 A6NML1
|
| Accessions |
EAW94276 EAW94277 EAW94278 Q86XP3 AB036090 BAC66466 AF083255 AAC32396 AF147429 AK001964 BAG50996 AK095772 BAG53126 AK096751 AK122737 BAG53696 AK126480 BAG54335 AK292908 BAF85597 AL050096 CAB43268 AL527653 AL545851 BC008208 AAH08208 BC015505 AAH15505 BC078667 AAH78667 BC093081 AAH93081 BK000566 DAA00077 DA440475 XM_006721657 XP_006721720 XM_011524259 XP_011522561 NM_007372 NP_031398 NM_203499 NP_987095
|
| Function |
ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.
|
| Subcellular Location |
Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.
|
| Tissue Specificity |
Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. {ECO:0000269|PubMed:10727850, ECO:0000269|PubMed:16397294}.
|
| Top Pathways |
Spliceosome
|