| Gene Symbol |
PTPRH
|
| Entrez Gene |
5794
|
| Alt Symbol |
R-PTP-H, SAP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, H
|
| Other Description |
receptor-type tyrosine-protein phosphatase H|stomach cancer-associated protein tyrosine phosphatase 1|transmembrane-type protein-tyrosine phosphatase type H
|
| Swissprots |
Q9HD43 C9JCH2 Q15426 Q2NKN9 Q2NKP0
|
| Accessions |
AAF91411 EAW72348 Q9HD43 AA573849 AK097257 BC111715 AAI11716 BC111716 AAI11717 D15049 BAA03645 XM_011527183 XP_011525485 XM_011527184 XP_011525486 XM_011527185 XP_011525487 XM_011527186 XP_011525488 XM_011527187 XP_011525489 XM_011527188 XP_011525490 XM_011527189 XP_011525491 XM_011527190 XP_011525492 XR_935847 NM_001161440 NP_001154912 NM_002842 NP_002833
|
| Function |
May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells. {ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}.
|
| Tissue Specificity |
Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness. {ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:12879010, ECO:0000269|PubMed:8294459}.
|