PTPRH

Gene Symbol PTPRH
Entrez Gene 5794
Alt Symbol R-PTP-H, SAP1
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, receptor type, H
Other Description receptor-type tyrosine-protein phosphatase H|stomach cancer-associated protein tyrosine phosphatase 1|transmembrane-type protein-tyrosine phosphatase type H
Swissprots Q9HD43 C9JCH2 Q15426 Q2NKN9 Q2NKP0
Accessions AAF91411 EAW72348 Q9HD43 AA573849 AK097257 BC111715 AAI11716 BC111716 AAI11717 D15049 BAA03645 XM_011527183 XP_011525485 XM_011527184 XP_011525486 XM_011527185 XP_011525487 XM_011527186 XP_011525488 XM_011527187 XP_011525489 XM_011527188 XP_011525490 XM_011527189 XP_011525491 XM_011527190 XP_011525492 XR_935847 NM_001161440 NP_001154912 NM_002842 NP_002833
Function May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells. {ECO:0000269|PubMed:11278335, ECO:0000269|PubMed:12101188, ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:15850787}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}.
Tissue Specificity Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness. {ECO:0000269|PubMed:12837766, ECO:0000269|PubMed:12879010, ECO:0000269|PubMed:8294459}.

GLEPP1 (C-16) - sc-33415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GLEPP1 (C-16): sc-33415. Western blot analysis of GLEPP1 expression in HeLa whole cell lysate.

Anti-SAP1 antibody - ab12556 from Abcam

Prices $380.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAP1 antibody (ab12556) at 1/500 dilutionLane 1 : SAP 1 (PTP RH)Lane 2 : PTPIA2 beta (PTP RN2)Lane 3 : GLEPP1 (PTP RO)Lane 4 : LAR (PTP RF)Lysates/proteins at 2.8 µg per lane.

Anti-SAP1 antibody - C-terminal - ab154912 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-SAP1 antibody - C-terminal (ab154912) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-PTPRH / SAP-1 Antibody (aa1038-1054) - LS-C3355 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PTPRH / SAP-1 Antibody - LS-C61781 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PTPRH / SAP-1 Antibody (aa576-625) - LS-C110795 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PTPRH antibody LS-C110795 Western blot of MCF7 cell lysate.

Anti-PTPRH / SAP-1 Antibody (aa844-1096) - LS-C314671 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant PTPRH / SAP-1.

PTPRH Antibody - NBP1-87091 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: PTPRH Antibody [NBP1-87091] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

PTPRH Antibody - NBP2-20005 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPRH Antibody [NBP2-20005] - Sample (30 ug of whole cell lysate) A: HeLa 7. 5% SDS PAGE gel, diluted at 1:1000.

PTPRH Antibody - NBP1-69289 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PTPRH Antibody [NBP1-69289] - This Anti-PTPRH antibody was used in Western Blot of MCF7 tissue lysate at a concentration of 1ug/ml.

PTPRH Antibody - NBP1-31497 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

PTPRH Antibody - NBP1-00229 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PTPRH antibody produced in rabbit - HPA042300 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PTPRH: <B>Cat. No. HPA042300</B>: Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Anti-PTPRH antibody produced in rabbit - SAB2101911 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PTPRH: <B>Cat. No.SAB2101911</B>: PTPRH in MCF7 cell lysate with PTPRH antibody at 1.0 μg/mL.

PTPRH antibody - middle region (ARP43522_P050) - ARP43522_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PTPRH-Antibody-interal-region - AF2718a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

PTPRH Antibody (OAEB00529) - OAEB00529 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

PTPRH antibody - 70R-7142 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SAP1 Antibody - AC21-1474 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (AMCA) - AC21-1474-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (AP) - AC21-1474-02 from Abcore

Prices $505.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (APC) - AC21-1474-03 from Abcore

Prices $515.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (APC-Cy5.5) - AC21-1474-04 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (APC-Cy7) - AC21-1474-05 from Abcore

Prices $539.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SAP1 Antibody (Avidin) - AC21-1474-06 from Abcore

Prices $519.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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