| Gene Symbol |
FIP1L1
|
| Entrez Gene |
81608
|
| Alt Symbol |
FIP1, Rhe, hFip1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
factor interacting with PAPOLA and CPSF1
|
| Other Description |
FIP1 like 1|FIP1-like 1 protein|FIP1L1 cleavage and polyadenylation specific factor subunit|factor interacting with PAP|pre-mRNA 3'-end-processing factor FIP1|rearranged in hypereosinophilia
|
| Swissprots |
Q96F80 G3XAD6 Q499Y4 Q49AU3 Q6UN15 Q7Z608 Q0VGE0 Q9H077 Q8WVN3 B4DIR3
|
| Accessions |
CAH05656 EAX05445 EAX05446 EAX05447 EAX05448 EAX05449 Q6UN15 AF161429 AAF28989 AK090938 AK123992 AK295737 BAG58575 AK300398 BAG62129 AK308145 AL136910 CAB66844 AM392758 CAL37636 AY366510 AAQ88277 BC011543 AAH11543 BC017724 AAH17724 BC024016 AAH24016 BC026724 BC052959 AAH52959 BC062768 BC110383 AAI10384 DN990103 XM_005265768 XP_005265825 XM_005265769 XP_005265826 XM_005265770 XP_005265827 XM_005265771 XP_005265828 XM_005265772 XP_005265829 XM_005265773 XP_005265830 XM_005265774 XP_005265831 XM_005265775 XP_005265832 XM_005265776 XP_005265833 XM_005265777 XP_005265834 XM_005265778 XP_005265835 XM_005265779 XP_005265836 XM_005265780 XP_005265837 XM_005265781 XP_005265838 XM_005265782 XP_005265839 NM_001134937 NP_001128409 NM_001134938 NP_001128410 NM_030917 NP_112179
|
| Function |
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. {ECO:0000269|PubMed:14749727}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
mRNA surveillance pathway
|