Il1b
| Gene Symbol | Il1b |
|---|---|
| Entrez Gene | 16176 |
| Alt Symbol | IL-1beta, Il-1b |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 1 beta |
| Other Description | IL-1 beta|interleukin-1 beta |
| Swissprots | P10749 Q2M4J6 |
| Accessions | AAX90604 CAA28637 EDL28238 P10749 AK156396 AK157245 AK168047 BAE40029 AK224980 AK225002 AK225003 BC011437 AAH11437 M15131 AAA39276 XM_006498795 XP_006498858 NM_008361 NP_032387 |
| Function | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| Subcellular Location | Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. |
| Top Pathways | Cytosolic DNA-sensing pathway, Apoptosis, Inflammatory bowel disease (IBD), Inflammatory mediator regulation of TRP channels, Toll-like receptor signaling pathway |
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