| Gene Symbol |
PELO
|
| Entrez Gene |
53918
|
| Alt Symbol |
CGI-17, PRO1770
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pelota homolog (Drosophila)
|
| Other Description |
protein pelota homolog
|
| Swissprots |
Q9Y306 Q9BRX2 Q9GZS6
|
| Accessions |
AAG22575 EAW54864 EAW54870 Q9BRX2 AF118075 AAF22019 AF132951 AAD27726 AF139828 AAG22574 AK025729 AK056144 BAG51633 AK312633 AY117399 AAM89414 BC005889 AAH05889 BC007249 AAH07249 BC007650 AAH07650 BC022789 AAH22789 DQ892950 ABM83876 DQ896198 ABM87197 NM_015946 NP_057030
|
| Function |
Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000250, ECO:0000305}.
|
| Subcellular Location |
Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11060452}.
|
| Top Pathways |
mRNA surveillance pathway
|