| Gene Symbol |
EXOSC3
|
| Entrez Gene |
51010
|
| Alt Symbol |
CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exosome component 3
|
| Other Description |
exosome complex component RRP40|exosome complex exonuclease RRP40|ribosomal RNA-processing protein 40
|
| Swissprots |
Q9NQT5 Q9Y3A8 Q5QP85 A8K0K6
|
| Accessions |
EAW58264 Q9NQT5 AF151860 AAD34097 AF229833 AAF42918 AF281132 AAF82133 AI886209 AK289571 BAF82260 AK290864 BAF83553 BC002437 AAH02437 BC008880 AAH08880 BE048144 BP237222 CA414231 CF994051 DA352003 DQ891938 ABM82864 DQ895125 ABM86051 NM_001002269 NP_001002269 NM_016042 NP_057126
|
| Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Nucleus.
|
| Top Pathways |
RNA degradation
|