EXOSC3

Gene Symbol EXOSC3
Entrez Gene 51010
Alt Symbol CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10
Species Human
Gene Type protein-coding
Description exosome component 3
Other Description exosome complex component RRP40|exosome complex exonuclease RRP40|ribosomal RNA-processing protein 40
Swissprots Q9NQT5 Q9Y3A8 Q5QP85 A8K0K6
Accessions EAW58264 Q9NQT5 AF151860 AAD34097 AF229833 AAF42918 AF281132 AAF82133 AI886209 AK289571 BAF82260 AK290864 BAF83553 BC002437 AAH02437 BC008880 AAH08880 BE048144 BP237222 CA414231 CF994051 DA352003 DQ891938 ABM82864 DQ895125 ABM86051 NM_001002269 NP_001002269 NM_016042 NP_057126
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus.
Top Pathways RNA degradation

EXOSC3 (B-8) - sc-166568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EXOSC3 (B-8): sc-166568. Western blot analysis of EXOSC3 expression in HeLa nuclear extract (A) and K-562 whole cell lysate (B).

EXOSC3 (FL-275) - sc-98776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EXOSC3 (FL-275): sc-98776. Immunofluorescence staining of formalin-fixed Hep G2 cells showing nucleolar localization.

EXOSC3 (Y-12) - sc-107213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-EXOSC3 antibody - ab156683 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EXOSC3 antibody (ab156683) at 0.1 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgLane 5 : mouse NIH3T3 whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-EXOSC3 antibody - ab88859 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EXOSC3 antibody (ab88859) at 1 µg/ml + human pancreas tissue lysate at 50 µg

Anti-EXOSC3 antibody - ab67661 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EXOSC3 antibody (ab67661) at 1/500 dilution + human pancreas tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-EXOSC3 antibody [4C9] - ab131655 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C9
All lanes : Anti-EXOSC3 antibody [4C9] (ab131655) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY EXOSC3 cDNA Lysates/proteins at 5 µg per lane.

Anti-EXOSC3 antibody [EPR14840(B)] - N-terminal - ab184961 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14840(B)
Immunofluorescent analysis of 4% paraformaldehyde fixed 293T cells labeling EXOSC3 with ab184961 at 1/100 dilution (red). Counterstained with Dapi (blue). 

Anti-EXOSC3 antibody [EPR14841] - C-terminal - ab190689 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14841
All lanes : Anti-EXOSC3 antibody [EPR14841] - C-terminal (ab190689) at 1/1000 dilutionLane 1 : Mouse kidney tissue lysateLane 2 : Mouse spleen tissue lysateLane 3 : Rat kidney tissue lysateLane 4 : Rat spleen tissue lysateLane 5 : RAW264.7 cell line lysateLane 6 : NIH 3T3 cell line lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated antibody at 1/1000 dilution

Anti-EXOSC3 antibody - Carboxyterminal end - ab76605 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EXOSC3 antibody - Carboxyterminal end (ab76605) at 1/50 dilution + HL60 cell line lysate at 35 µg

Anti-EXOSC3 Antibody (C-Terminus) - LS-C80306 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 10-20%.

Anti-EXOSC3 Antibody (C-Terminus) - LS-C30681 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
EXOSC3 antibody LS-C30681 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-EXOSC3 Antibody (aa81-130) - LS-C30370 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EXOSC3 antibody LS-C30370 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-EXOSC3 Antibody (clone 4C9) - LS-C173985 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EXOSC3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EXOSC3.

Anti-EXOSC3 Antibody - LS-C307457 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-EXOSC3 Antibody (aa152-201) - LS-C205712 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EXOSC3 / p10 antibody Western Blot of Esophagus Tumor. Antibody dilution: 1 ug/ml.

Anti-EXOSC3 Antibody - LS-C310294 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC3 Antibody - LS-C310295 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EXOSC3 / p10 Antibody (aa1-276, Azide-free) - LS-C327341 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-EXOSC3 Antibody (clone 1D6) - LS-C173984 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY EXOSC3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-EXOSC3.

Anti-EXOSC3 Antibody (clone 5C3) - LS-C133747 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5C3
Immunoperoxidase of monoclonal antibody to EXOSC3 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]

Anti-EXOSC3 Antibody (aa225-275) - LS-C290556 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EXOSC3 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-EXOSC3 antibody used for IP at 6 ug/mg lysate. EXOSC3 was also immunoprecipitated by rabbit anti-EXOSC3 antibody BL14007. For blotting immunoprecipitated EXOSC3, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

EXOSC3 Antibody - NBP2-22261 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EXOSC3 Antibody [NBP2-22261] - Whole cell lysate from 293T (15 and 50 ug), HeLa (50 ug), Jurkat (50 ug), and mouse NIH3T3 (50 ug) cells. NBP2-22261 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

EXOSC3 Antibody - NBP1-57209 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EXOSC3 Antibody [NBP1-57209] - Jurkat cell lysate, Antibody Titration: 0.2-1 ug/ml

EXOSC3 Antibody - NBP2-16392 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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