EXOSC3

Gene Symbol	EXOSC3
Entrez Gene	51010
Alt Symbol	CGI-102, PCH1B, RRP40, Rrp40p, bA3J10.7, hRrp-40, p10
Species	Human
Gene Type	protein-coding
Description	exosome component 3
Other Description	exosome complex component RRP40|exosome complex exonuclease RRP40|ribosomal RNA-processing protein 40
Swissprots	Q9NQT5 Q9Y3A8 Q5QP85 A8K0K6
Accessions	EAW58264 Q9NQT5 AF151860 AAD34097 AF229833 AAF42918 AF281132 AAF82133 AI886209 AK289571 BAF82260 AK290864 BAF83553 BC002437 AAH02437 BC008880 AAH08880 BE048144 BP237222 CA414231 CF994051 DA352003 DQ891938 ABM82864 DQ895125 ABM86051 NM_001002269 NP_001002269 NM_016042 NP_057126
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC3 full length protein - ab162388 from Abcam Category Protein Source Wheat germ Species Human

Human EXOSC3 full length protein - ab181889 from Abcam Category Protein Source E. coli Species Human

Human EXOSC3 protein fragment - ab162389 from Abcam Category Protein Source Wheat germ Species Human

EXOSC3 Antibody Blocking Peptide - LS-E14643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC3 Antibody Blocking Peptide - LS-E14644 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC3 Antibody Blocking Peptide - LS-E14964 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EXOSC3 Recombinant Protein - H00051010-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

EXOSC3 Partial Recombinant Protein - H00051010-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EXOSC3 Blocking Peptide - 33R-9596 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC3 Blocking Peptide - 33R-9133 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC3 Blocking Peptide - 33R-7189 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EXOSC3 protein (His tag) - 80R-3836 from Fitzgerald Category Protein Prices $275.00 Sizes 10 µg Source E.coli

EXOSC3 (1-275, His-tag) - AR51523PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

EXOSC3 (1-275, His-tag) - AR51523PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

EXOSC3 - H00051010-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC3 - H00051010-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC3 / Exosome component 3 - H00051010-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

EXOSC3, 1-275aa, Human, His tag, E.coli - 01-P2703 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

EXOSC3 fusion protein - Ag7065 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EXOSC3, GST-tagged - EXOSC3-12596H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EXOSC3, His-tagged - EXOSC3-210H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP40(EXOSC3) - CSB-YP889083HU CSB-EP889083HU CSB-BP889083HU CSB-MP889083HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC3, 1-275aa, Human, His tag, E.coli - ATGP2703 from ATGen Category Protein Prices $240.00, $720.00 Sizes 10 µg, 50 µg Species Human

EXOSC3 (transcript variant 1) - TP300035 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EXOSC3 (transcript variant 2) - TP318361 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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