CLCA1

Gene Symbol CLCA1
Entrez Gene 1179
Alt Symbol CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1
Species Human
Gene Type protein-coding
Description chloride channel accessory 1
Other Description CLCA family member 1, chloride channel regulator|calcium-activated chloride channel family member 1|calcium-activated chloride channel protein 1|calcium-activated chloride channel regulator 1|calcium-dependent chloride channel-1|chloride channel regulator 1|chloride channel, calcium activated, family member 1
Swissprots Q9UNF6 O95151 Q9UPC6 Q5TDF4 A8K7I4 B2RAV5
Accessions A8K7I4 AAC95429 EAW73186 AA508854 AF039400 AAC95428 AF127036 AAD25487 AK024970 AK097057 BAG53415 AK291999 BAF84688 AK300858 BAG62508 AK314375 BAG37002 AW361520 AW750670 BC141451 AAI41452 BC156805 AAI56806 DA428844 NM_001285 NP_001276
Function May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.
Subcellular Location Secreted, extracellular space {ECO:0000269|PubMed:15919655}. Cell membrane {ECO:0000269|PubMed:15919655}; Peripheral membrane protein {ECO:0000269|PubMed:15919655}; Extracellular side {ECO:0000269|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Tissue Specificity Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:16012037, ECO:0000269|PubMed:9828122}.
Top Pathways Olfactory transduction, Pancreatic secretion

CLCA1 (E-4) - sc-271156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLCA1 (E-4): sc-271156. Western blot analysis of CLCA1 expression in HCT 116 (A) and Ramos (B) whole cell lysates.

CLCA1 (M-16) - sc-46865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLCA1 (M-16): sc-46865. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of goblet cells.

CLCA1 (H-54) - sc-67157 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CLCA1 (H-54): sc-67157. Western blot analysis of CLCA1 expression in mouse liver tissue extract.

CLCA1 (N-14) - sc-46866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CLCA1 antibody - ab96131 from Abcam

Prices $304.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CLCA1 antibody (ab96131) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-CLCA1 antibody - ab109729 from Abcam

Host Goat
Clonality Polyclonal
Anti-CLCA1 antibody (ab109729) at 0.3 µg/ml + Human Lung lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-CLCA1 antibody - ab77540 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CLCA1 antibody (ab77540) at 0.3 µg/ml + Human lung lysate at 35 µg

Anti-CLCA1 antibody - ab54662 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54662 CLCA1 antibody at 1ug/ml.

Anti-CLCA1 antibody [1C4] - ab129283 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
ab129283, at 2.5 µg/ml, staining CLCA1 in Formalin-fixed, Paraffin-embedded Human colon, goblet cells tissue by Immunohistochemistry.

Anti-CLCA1 antibody [EPR12254] - ab174319 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12254
Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling CLCA1 with ab174319 at 1/100 dilution.

Anti-CLCA1 antibody [EPR12254-88] - ab180851 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12254-88
Immunofluorescence analysis of A431 cells labeling CLCA1 using ab180851 at 1/50 dilution.

Anti-GOB5 / CLCA1 Antibody (clone 1C4) IHC-plus™ - LS-B6384 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
Anti-CLCA1 antibody IHC of human colon, goblet cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6384 concentration 2.5 ug/ml.

Anti-GOB5 / CLCA1 Antibody (aa542-633) - LS-C185346 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded gastric CA using CLCA1 antibody at 1:100 dilution.

Anti-GOB5 / CLCA1 Antibody (aa872-884) IHC-plus™ - LS-B4111 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CLCA1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4111 concentration 3.75 ug/ml.

Anti-GOB5 / CLCA1 Antibody (aa592-603) - LS-C54658 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GOB5 / CLCA1 Antibody (aa416-670, Biotin) - LS-C298576 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GOB5 / CLCA1 Antibody (aa416-670, FITC) - LS-C301880 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GOB5 / CLCA1 Antibody (aa416-670) - LS-C293307 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GOB5 / CLCA1.

CLCA1 Antibody - NBP1-31129 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CLCA1 Antibody [NBP1-31129] - (30 ug of whole cell lysate) A431 7. 5% SDS PAGE, antibody diluted at 1:1000.

CLCA1 Antibody - NB100-1791 from Novus Biologicals

Prices $259.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: CLCA1 Antibody [NB100-1791] (1ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CLCA1 Antibody - NBP2-38869 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: CLCA1 Antibody [NBP2-38869] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells / Goblet cells strongly stained.

CLCA1 Antibody - NBP1-05038 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: CLCA1 Antibody [NBP1-05038] - Analysis of CLCA1 in Human Lung lysate at 0.3ug/ml (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CLCA1 Antibody (2C10) - H00001179-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C10

CLCA1 Antibody (1C4) - H00001179-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4

Monoclonal Anti-CLCA1 antibody produced in mouse - SAB1403674 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
<B>Immunoblotting</B><BR/>Monoclonal Anti-CLCA1: <B>Cat. No. SAB1403674</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.
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