| Gene Symbol |
CLCA1
|
| Entrez Gene |
1179
|
| Alt Symbol |
CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel accessory 1
|
| Other Description |
CLCA family member 1, chloride channel regulator|calcium-activated chloride channel family member 1|calcium-activated chloride channel protein 1|calcium-activated chloride channel regulator 1|calcium-dependent chloride channel-1|chloride channel regulator 1|chloride channel, calcium activated, family member 1
|
| Swissprots |
Q9UNF6 O95151 Q9UPC6 Q5TDF4 A8K7I4 B2RAV5
|
| Accessions |
A8K7I4 AAC95429 EAW73186 AA508854 AF039400 AAC95428 AF127036 AAD25487 AK024970 AK097057 BAG53415 AK291999 BAF84688 AK300858 BAG62508 AK314375 BAG37002 AW361520 AW750670 BC141451 AAI41452 BC156805 AAI56806 DA428844 NM_001285 NP_001276
|
| Function |
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000269|PubMed:15919655}. Cell membrane {ECO:0000269|PubMed:15919655}; Peripheral membrane protein {ECO:0000269|PubMed:15919655}; Extracellular side {ECO:0000269|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
|
| Tissue Specificity |
Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:16012037, ECO:0000269|PubMed:9828122}.
|
| Top Pathways |
Olfactory transduction, Pancreatic secretion
|