CLCA1

Gene Symbol	CLCA1
Entrez Gene	1179
Alt Symbol	CACC, CACC1, CLCRG1, CaCC-1, GOB5, hCLCA1, hCaCC-1
Species	Human
Gene Type	protein-coding
Description	chloride channel accessory 1
Other Description	CLCA family member 1, chloride channel regulator|calcium-activated chloride channel family member 1|calcium-activated chloride channel protein 1|calcium-activated chloride channel regulator 1|calcium-dependent chloride channel-1|chloride channel regulator 1|chloride channel, calcium activated, family member 1
Swissprots	Q9UNF6 O95151 Q9UPC6 Q5TDF4 A8K7I4 B2RAV5
Accessions	A8K7I4 AAC95429 EAW73186 AA508854 AF039400 AAC95428 AF127036 AAD25487 AK024970 AK097057 BAG53415 AK291999 BAF84688 AK300858 BAG62508 AK314375 BAG37002 AW361520 AW750670 BC141451 AAI41452 BC156805 AAI56806 DA428844 NM_001285 NP_001276
Function	May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.
Subcellular Location	Secreted, extracellular space {ECO:0000269|PubMed:15919655}. Cell membrane {ECO:0000269|PubMed:15919655}; Peripheral membrane protein {ECO:0000269|PubMed:15919655}; Extracellular side {ECO:0000269|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
Tissue Specificity	Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in. {ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:16012037, ECO:0000269|PubMed:9828122}.
Top Pathways	Olfactory transduction, Pancreatic secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CLCA1 peptide (592-603) - ab45746 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human CLCA1 protein fragment - ab114722 from Abcam Category Protein Source Wheat germ Species Human

GOB5 / CLCA1 Antibody Blocking Peptide - LS-E25893 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GOB5 / CLCA1 Antibody Blocking Peptide - LS-E26738 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CLCA1 Protein - H00001179-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CLCA1 (aa872-884) blocking peptide - GTX88552-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

CLCA1 blocking peptide - GTX89537-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

CLCA1 Immunizing peptide - orb16223 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human CLCA1 Protein - abx065870 from Abbexa Category Protein Source E.coli Species Human

CLCA1 Peptide - AC21-0723-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CLCA1 Peptide - AC21-1575-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CLCA1 - H00001179-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLCA1 - H00001179-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Chloride Channel Accessory 1 (CLCA1), Human - 20-9190 from ARP American Research Products Category Protein Prices $539.00 Sizes 50 µg Source E.coli Species Human

CLCA1 Peptide - 46-734P from ProSci Category Peptide Species Human

CLCA1 Peptide - 45-405P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CLCA1 fusion protein - ag18176 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CLCA1 fusion protein - Ag18265 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CLCA1 - CLCA1-27070TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CLCA1, His-tagged - CLCA1-11273H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Chloride Channel Accessory 1 (CLCA1) - RPG669Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Chloride Channel Accessory 1 (CLCA1) - RPG669Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Calcium-activated chloride channel regulator 1(CLCA1) ,partial - CSB-YP005474HU CSB-EP005474HU CSB-BP005474HU CSB-MP005474HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Chloride Channel Accessory 1 (CLCA1) - RPU140774 from Biomatik Category Protein Prices $258.50, $517.00, $775.50 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

Calcium-activated chloride channel regulator 1 (CLCA1), partial, Recombinant Protein - MBS1264584 from MyBioSource Category Protein Prices $930.00, $930.00, $1,155.00, $1,155.00, $1,330.00, $1,330.00, $1,790.00, $1,790.00, $1,825.00, $2,620.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more