CHP1

Gene Symbol CHP1
Entrez Gene 11261
Alt Symbol CHP, SLC9A1BP, Sid470p, p22, p24
Species Human
Gene Type protein-coding
Description calcineurin-like EF-hand protein 1
Other Description EF-hand calcium-binding domain-containing protein p22|SLC9A1 binding protein|calcineurin B homolog|calcineurin B homologous protein 1|calcineurin B-like protein|calcineurin homologous protein|calcineurin-like EF hand protein 1|calcium binding protein P22|calcium-binding protein CHP|calcium-binding protein p22
Swissprots Q6FHZ9 B2R6H9 Q99653
Accessions EAW92474 EAW92475 EAW92476 EAW92477 Q99653 AK000095 AK094363 AK299660 BAG61577 AK307060 AK312582 BAG35476 AV761136 BC008373 BC031293 AAH31293 BC062538 BC073809 BC080653 BE250654 BG398684 BI491312 BM828547 BQ213482 BX391712 CR536539 CAG38776 CR542085 CAG46882 U61538 AAB37770 XM_005254140 XP_005254197 NM_007236 NP_009167
Function Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucl
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633}. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarit
Tissue Specificity Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. {ECO:0000269|PubMed:8901634}.

CHP (E-14) - sc-160240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHP (E-14): sc-160240. Western blot analysis of CHP expression in HeLa (A) and U-698-M (B) whole cell lysates.

CHP (H-52) - sc-366687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CHP (N-13) - sc-160241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Calcium binding protein P22 antibody - ab96203 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Calcium binding protein P22 antibody (ab96203) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-Calcium binding protein P22 antibody - ab56953 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56953 Calcium binding protein P22 antibody at 1ug/ml.

Anti-Calcium binding protein P22 antibody - N-terminal - ab196807 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Calcium binding protein P22 antibody - N-terminal (ab196807) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract with synthesized peptide

Anti-SLC9A1BP / CHP Antibody (Internal, AP) - LS-C254767 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (Internal, Biotin) - LS-C254769 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (Internal, APC) - LS-C254768 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (Internal, FITC) - LS-C254770 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (Internal, Azide-free, HRP) - LS-C254771 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (Internal, PE) - LS-C254772 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody - LS-C309909 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (clone S2) - LS-C306952 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S2

Anti-SLC9A1BP / CHP Antibody (Internal) - LS-C320366 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1BP / CHP Antibody (aa47-141) - LS-C186231 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of methanol-fixed HepG2 using Calcium binding protein P22 antibody at 1:200 dilution.

Anti-SLC9A1BP / CHP Antibody (aa35-84) IHC-plus™ - LS-B10321 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC9A1BP / CHP antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10321 concentration 10 ug/ml.

Calcium-binding-protein-P22 Antibody - H00011261-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Calcium-binding-protein-P22 Antibody [H00011261-D01P] - Analysis of CHP expression in transfected 293T cell line by CHP polyclonal antibody.Lane 1: CHP transfected lysate(22.50 KDa).Lane 2: Non-transfected lysate.

Calcium-binding-protein-P22 Antibody (S2) - H00011261-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S2
Sandwich ELISA: Calcium-binding-protein-P22 Antibody (S2) [H00011261-M02] - Detection limit for recombinant GST tagged CHP is approximately 0.3ng/ml as a capture antibody.

Calcium-binding-protein-P22 Antibody (3G8) - H00011261-M01 from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3G8

Anti-CHP, (N-terminal) antibody produced in rabbit - SAB2105833 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHP (N-Terminal): <B>Cat. No. SAB2105833</B>: CHP in 721_B cell lysates with CHP antibody at 0.25μg/mL.

Anti-CHP antibody produced in rabbit - SAB1408668 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHP: <B>Cat. No. SAB1408668</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~22.5 kDa using CHP transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Monoclonal Anti-CHP antibody produced in mouse - SAB1404922 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S2
<B>Immunoblotting</B><BR/>Monoclonal Anti-CHP: <B>Cat. No. SAB1404922</B>: Antibody concentration: 1 μg/mL. Specific band of ~33.4 kDa using immunogen protein lysate.

Anti-CHP1 antibody produced in rabbit - HPA006616 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AC012652.1: <B>Cat. No. HPA006616</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hippocampus shows strong cytoplasmic and nuclear(nucleolar) positivity in neuronal cells.

Monoclonal Anti-CHP antibody produced in mouse - WH0011261M1 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3G8
<B>Immunoblotting</B><BR/>Monoclonal Anti-CHP, <B>Cat. No. WH0011261M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~33.37 kDa using immunogen protein lysate.
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