CHP1

Gene Symbol	CHP1
Entrez Gene	11261
Alt Symbol	CHP, SLC9A1BP, Sid470p, p22, p24
Species	Human
Gene Type	protein-coding
Description	calcineurin-like EF-hand protein 1
Other Description	EF-hand calcium-binding domain-containing protein p22|SLC9A1 binding protein|calcineurin B homolog|calcineurin B homologous protein 1|calcineurin B-like protein|calcineurin homologous protein|calcineurin-like EF hand protein 1|calcium binding protein P22|calcium-binding protein CHP|calcium-binding protein p22
Swissprots	Q6FHZ9 B2R6H9 Q99653
Accessions	EAW92474 EAW92475 EAW92476 EAW92477 Q99653 AK000095 AK094363 AK299660 BAG61577 AK307060 AK312582 BAG35476 AV761136 BC008373 BC031293 AAH31293 BC062538 BC073809 BC080653 BE250654 BG398684 BI491312 BM828547 BQ213482 BX391712 CR536539 CAG38776 CR542085 CAG46882 U61538 AAB37770 XM_005254140 XP_005254197 NM_007236 NP_009167
Function	Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucl
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633}. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarit
Tissue Specificity	Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. {ECO:0000269|PubMed:8901634}.

• Antibodies
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Calcium binding protein P22 full length protein - ab99141 from Abcam Category Protein Prices $188.00, $692.00 Sizes 100 µg, 500 µg Source E. coli Species Human

SLC9A1BP / CHP Antibody Blocking Peptide - LS-E18805 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHP-Antibody-Center-Blocking-Peptide - BP8625c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHP Protein (OPPA02266) - OPPA02266 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

CHP protein (His tag) - 80R-1360 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

Calcium-binding protein p22 (1-195, His-tag) - AR09534PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

Calcium-binding protein p22 (1-195, His-tag) - AR09534PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

Calcium-binding protein p22 - H00011261-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Calcium-binding protein p22 - H00011261-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHP, 1-195aa, Human, His tag, E.coli - 01-1857 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CHP fusion protein - Ag8488 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CHP fusion protein - ag8815 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Calcium Binding Protein P22 - BP001549-PRO-847 from Syd Labs Category Protein Prices $160.00, $2,250.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

CHP, 1-195aa, Recombinant Protein - GWB-P1441K from Genway Biotech Category Protein Prices $260.00, $780.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Lcium Binding Protein P22, His-tagged - CHP-2583H from Creative Biomart Category Protein Source E.coli.

Recombinant Human CHP, GST-tagged - CHP-11197H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CHP1 - CHP1-822H from Creative Biomart Category Protein Source Mammalian Cells Species Human

CHP 1-195aa - CMB-430 from Reagent Proteins Category Protein Prices $441.00, $805.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Human Calcium-binding protein p22(CHP) - CSB-YP860773HU CSB-EP860773HU CSB-BP860773HU CSB-MP860773HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHP, 1-195aa, Human, His tag, E.coli - ATGP0597 from ATGen Category Protein Prices $70.00, $210.00, $625.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Calcium-binding protein p22 - TP301928 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Calcium Binding Protein P22, Recombinant Protein - MBS143952 from MyBioSource Category Protein Prices $140.00, $205.00, $2,235.00 Sizes 5 µg, 25 µg, 1 mg Source E Coli

Calcium-binding protein p22 (CHP), Recombinant Protein - MBS1470235 from MyBioSource Category Protein Prices $940.00, $940.00, $1,165.00, $1,165.00, $1,400.00, $1,400.00, $1,865.00, $1,865.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CHP - PAT-80646-1 from Nordic BioSite Category Protein Species Human

CHP - PAT-80646-2 from Nordic BioSite Category Protein Species Human

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