| Gene Symbol | CHP1 |
|---|---|
| Entrez Gene | 11261 |
| Alt Symbol | CHP, SLC9A1BP, Sid470p, p22, p24 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcineurin-like EF-hand protein 1 |
| Other Description | EF-hand calcium-binding domain-containing protein p22|SLC9A1 binding protein|calcineurin B homolog|calcineurin B homologous protein 1|calcineurin B-like protein|calcineurin homologous protein|calcineurin-like EF hand protein 1|calcium binding protein P22|calcium-binding protein CHP|calcium-binding protein p22 |
| Swissprots | Q6FHZ9 B2R6H9 Q99653 |
| Accessions | EAW92474 EAW92475 EAW92476 EAW92477 Q99653 AK000095 AK094363 AK299660 BAG61577 AK307060 AK312582 BAG35476 AV761136 BC008373 BC031293 AAH31293 BC062538 BC073809 BC080653 BE250654 BG398684 BI491312 BM828547 BQ213482 BX391712 CR536539 CAG38776 CR542085 CAG46882 U61538 AAB37770 XM_005254140 XP_005254197 NM_007236 NP_009167 |
| Function | Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucl |
| Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633}. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarit |
| Tissue Specificity | Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen. {ECO:0000269|PubMed:8901634}. |