Gene Symbol | NEUROD2 |
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Entrez Gene | 4761 |
Alt Symbol | NDRF, bHLHa1 |
Species | Human |
Gene Type | protein-coding |
Description | neuronal differentiation 2 |
Other Description | class A basic helix-loop-helix protein 1|neuroD-related factor|neurogenic basic-helix-loop-helix protein|neurogenic differentiation 2|neurogenic differentiation factor 2 |
Swissprots | Q15784 Q9UQC6 Q8TBI7 |
Accessions | AAC26058 EAW60579 Q15784 AB021742 BAA77569 AW134767 BC022481 AAH22481 BT019365 AAV38172 XM_005257409 XP_005257466 XM_011524851 XP_011523153 NM_006160 NP_006151 |
Function | Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}. |
Human NeuroD2 full length protein - ab152568 from Abcam
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NEUROD2 Antibody Blocking Peptide - LS-E27663 from LifeSpan Bioscience
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NEUROD2 Antibody Blocking Peptide - LS-E11196 from LifeSpan Bioscience
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NEUROD2 Antibody Blocking Peptide - LS-E26026 from LifeSpan Bioscience
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NeuroD2 Partial Recombinant Protein - H00004761-Q01 from Novus Biologicals
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Recombinant Human NeuroD2 Protein - H00004761-P01 from Novus Biologicals
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NEUROD2 peptide - orb217658 from Biorbyt
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NEUROD2 Blocking Peptide - abx062989 from Abbexa
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NEUROD2 Peptide - AC21-0854-P from Abcore
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NeuroD2 Peptide - AC21-2481-P from Abcore
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NEUROD2 - H00004761-P01 from Acris Antibodies
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NEUROD2 - H00004761-Q01-10 from Acris Antibodies
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NEUROD2 - H00004761-Q01-25 from Acris Antibodies
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NEUROD2 Peptide - 45-953P from ProSci
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NEUROD2 Blocking Peptide - CBP1795 from Cohesion Biosciences
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Neuro D2 (D94) Peptide - BS2316P from Bioworld Technology
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Recombinant Human Neurogenic differentiation factor 2(NEUROD2) - CSB-YP614900HU CSB-EP614900HU CSB-BP614900HU CSB-MP614900HU from Cusabio
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NEUROD2 - TP305293 from Acris Antibodies
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NEUROD2, Peptide - MBS425870 from MyBioSource
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NEUROD2, Peptide - MBS427991 from MyBioSource
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NEUROD2 fusion protein - Ag25223 from Proteintech Group
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NEUROD2 Peptide, Human - M34GP10315H from Creative Peptides
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NEUROD2 Immunizing peptide - orb17924 from Biorbyt
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Neurogenic differentiation factor 2 (NEUROD2), Recombinant Protein - MBS1461750 from MyBioSource
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NEUROD2 fusion protein - Ag26068 from Proteintech Group
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