MAGOH

Gene Symbol MAGOH
Entrez Gene 4116
Alt Symbol MAGOH1, MAGOHA
Species Human
Gene Type protein-coding
Description mago-nashi homolog, proliferation-associated (Drosophila)
Other Description protein mago nashi homolog
Swissprots O35169 Q5SW69 B2R5A2 B1ARP8 P50606 P61326
Accessions EAX06747 EAX06748 P61326 AF035940 AAC39606 AF067173 AAD32457 AF086246 AK297895 BAG60216 AK312113 BAG35049 BC018211 AAH18211 BX283982 DQ891289 ABM82215 DQ894473 ABM85399 NM_002370 NP_002361
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway

MAGOH (C-11) - sc-271405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAGOH (C-11): sc-271405. Western blot analysis of MAGOH expression in HL-60 (A) and HeLa (B) nuclear extracts and Raji whole cell lysate (C).

MAGOH (N-17) - sc-48240 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAGOH (N-17): sc-48240. Western blot analysis of MAGOH expression in non-transfected: sc-110760 (A) and human MAGOH transfected: sc-113018 (B) 293 whole cell lysates.

MAGOH (H-117) - sc-99124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAGOH (H-117): sc-99124. Western blot analysis of MAGOH expression in PC-3 whole cell lysate.

MAGOH (C-12) - sc-48237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MAGOH (N-15) - sc-48239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MAGOH (21B12) - sc-56724 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAGOH (21B12): sc-56724. Western blot analysis of MAGOH expression in non-transfected: sc-110760 (A) and human MAGOH transfected: sc-113018 (B) 293 whole cell lysates.

MAGOH (F-6) - sc-271365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAGOH (F-6): sc-271365. Western blot analysis of MAGOH expression in HL-60 (A) and HeLa (B) nuclear extracts and Raji whole cell lysate (C).

Anti-MAGOH antibody - ab123399 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MAGOH antibody (ab123399) at 1/100 dilution + K-562 cell line lysates at 35 µg

Anti-MAGOH antibody - ab55440 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MAGOH antibody [EPR10745] - ab170944 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10745
Immunohistochemistry analysis of paraffin-embedded Human kidney tissue labeling MAGOH with ab170944 at 1/50 dilution.

Anti-MAGOH antibody [EPR14037] - ab180505 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14037
All lanes : Anti-MAGOH antibody [EPR14037] (ab180505) at 1/2000 dilutionLane 1 : Hela cell lysateLane 2 : Raji cell lysateLane 3 : Jurkat cell lysateLane 4 : HL60 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-MAGOH Antibody (aa46-74, AP) - LS-C223127 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa46-74, APC) - LS-C223129 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa46-74, Biotin) - LS-C223130 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa46-74, FITC) - LS-C223131 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa46-74, Azide-free, HRP) - LS-C223132 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa46-74, PE) - LS-C223133 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa98-109) - LS-C55081 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
MAGOH antibody (1 ug/ml) staining of nuclear HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-MAGOH Antibody (aa45-74) - LS-C322805 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAGOH Antibody (aa1-111, Azide-free) - LS-C327807 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MAGOH Antibody (aa31-80) - LS-C135763 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAGOH antibody LS-C135763 Western blot of MCF7 cell lysate.

Anti-MAGOH Antibody - LS-C334476 from LifeSpan Bioscience

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using MAGOH antibody.

Anti-MAGOH Antibody (aa46-74) - LS-C163974 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MAGOH Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-MAGOH Antibody (clone 6E11) - LS-C139276 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6E11
Western blot of MAGOH expression in transfected 293T cell line by MAGOH monoclonal antibody (M01), clone 6E11.

MAGOH Antibody - NBP1-79807 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MAGOH Antibody [NBP1-79807] - Titration: 0.2-1 ug/ml, Positive Control: MCF7 cell lysate.
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