MAGOH

Gene Symbol	MAGOH
Entrez Gene	4116
Alt Symbol	MAGOH1, MAGOHA
Species	Human
Gene Type	protein-coding
Description	mago-nashi homolog, proliferation-associated (Drosophila)
Other Description	protein mago nashi homolog
Swissprots	O35169 Q5SW69 B2R5A2 B1ARP8 P50606 P61326
Accessions	EAX06747 EAX06748 P61326 AF035940 AAC39606 AF067173 AAD32457 AF086246 AK297895 BAG60216 AK312113 BAG35049 BC018211 AAH18211 BX283982 DQ891289 ABM82215 DQ894473 ABM85399 NM_002370 NP_002361
Function	Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location	Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	Spliceosome, RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAGOH full length protein - ab95308 from Abcam Category Protein Source E. coli Species Human

Human MAGOH full length protein - ab117170 from Abcam Category Protein Source E. coli Species Human

Human MAGOH peptide - ab28608 from Abcam Category Peptide

MAGOH-Antibody-Center-Blocking-Peptide - BP14367c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAGOH Protein (OPPA02328) - OPPA02328 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

MAGOH protein (His tag) - 80R-1303 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

MAGOH Peptide - AC21-0209-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MAGOH (1-146, His-tag) - AR09448PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

MAGOH (1-146, His-tag) - AR09448PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

MAGOH - H00004116-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MAGOH - H00004116-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MAGOH - H00004116-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAGOH - H00004116-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAGOH, 1-146 aa, Human, His-tagged, Recombinant, E.coli - 01-1820 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

MAGOH Peptide - 45-856P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MAGOH fusion protein - Ag3004 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAGOH Human - PRPS-817 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human MAGOH Protein - BP001773-PRO-810 from Syd Labs Category Protein Prices $160.00, $2,250.00 Sizes 25 µg, 1 mg Source Escherichia Coli-derived. Species Human

MAGOH, 1-146 aa, Recombinant Protein - GWB-P1500E from Genway Biotech Category Protein Prices $260.00, $780.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human MAGOH, His-tagged - MAGOH-30167TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MAGOH, His-tagged - MAGOH-30169TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MAGOH, His-tagged - MAGOH-334H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MAGOH, His-tagged - MAGOH-2364H from Creative Biomart Category Protein Source E.coli.

MAGOH 1-146 aa - CMB-371 from Reagent Proteins Category Protein Prices $441.00, $805.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

MAGOH Human - NKX-450 from Reagent Proteins Category Protein Prices $348.00, $2,588.00 Sizes 25.00 µg, 1 mg Source E.coli Species Human

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