MAGOH

Gene Symbol MAGOH
Entrez Gene 4116
Alt Symbol MAGOH1, MAGOHA
Species Human
Gene Type protein-coding
Description mago-nashi homolog, proliferation-associated (Drosophila)
Other Description protein mago nashi homolog
Swissprots O35169 Q5SW69 B2R5A2 B1ARP8 P50606 P61326
Accessions EAX06747 EAX06748 P61326 AF035940 AAC39606 AF067173 AAD32457 AF086246 AK297895 BAG60216 AK312113 BAG35049 BC018211 AAH18211 BX283982 DQ891289 ABM82215 DQ894473 ABM85399 NM_002370 NP_002361
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP- bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and transla
Subcellular Location Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway

MAGOH CRISPR/Cas9 KO Plasmid (h) - sc-402667 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH HDR Plasmid (h) - sc-402667-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH Double Nickase Plasmid (h) - sc-402667-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH Double Nickase Plasmid (h2) - sc-402667-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH CRISPR Activation Plasmid (h) - sc-402667-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH CRISPR Activation Plasmid (h2) - sc-402667-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH Lentiviral Activation Particles (h) - sc-402667-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH Lentiviral Activation Particles (h2) - sc-402667-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAGOH siRNA (h) - sc-60978 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAGOH shRNA Plasmid (h) - sc-60978-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAGOH shRNA (h) Lentiviral Particles - sc-60978-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU143241 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12944 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12944 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00946 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00946

MAGOH siRNA (Human) - CRH2795 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAGOH (NM_002370.3) - SHH337055 from Creative biogene

Category siRNA
Species Reactivities Human

Human MAGOH siRNA - orb263297 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MAGOH shRNA Plasmid (Human) - CHH2795 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAGOH miRNA 3'UTR clone - MiUTR3H-05121 from Creative biogene

Species Reactivities Human
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