LIMD1

Gene Symbol	LIMD1
Entrez Gene	8994
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	LIM domains containing 1
Other Description	LIM domain-containing protein 1
Swissprots	Q9NQ47 Q9BQQ9 Q17RQ1 Q9UGP4
Accessions	CAB95944 CAC35917 EAW64742 Q9UGP4 AJ132408 CAB63652 AK021508 BC027712 BC117236 AAI17237 BC117238 AAI17239 BU428864 HQ258355 ADR83109 M80651 XM_005265529 XP_005265586 XM_011534207 XP_011532509 NM_014240 NP_055055
Function	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of T
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down- regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
Tissue Specificity	Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. {ECO:0000269|PubMed:10647888, ECO:0000269|PubMed:18712738}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LIMD1 Antibody - 13245 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Limd1 (E-10) - sc-365050 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Limd1 (E-15) - sc-55843 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Limd1 (H-4) - sc-271448 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Limd1 (C-16) - sc-55841 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Limd1 (H-57) - sc-134932 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Limd1 (N-20) - sc-55845 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-LIMD1 antibody - ab118367 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-LIMD1 antibody - C-terminal - ab155788 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (N-Terminus) IHC-plus™ - LS-B4017 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa395-593) - LS-C179147 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, AP) - LS-C237127 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, APC) - LS-C237128 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, FITC) - LS-C237129 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, Biotin) - LS-C237130 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, PE) - LS-C237131 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467, Azide-free, HRP) - LS-C248709 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa1-50) - LS-C289878 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa50-100) - LS-C289880 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (aa437-467) - LS-C322658 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (N-Terminus) - LS-C210562 from LifeSpan Bioscience Prices $360.00 Sizes 500 µl Host Rabbit Clonality Polyclonal

Anti-LIMD1 Antibody (clone 2G5) - LS-C133991 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G5

Anti-LIMD1 Antibody (aa438-467) IHC-plus™ - LS-B9619 from LifeSpan Bioscience Prices $395.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

LIMD1 Antibody - 46370002 from Novus Biologicals Prices $299.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

LIMD1 Antibody (2G5) - H00008994-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G5

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