LIMD1

Gene Symbol	LIMD1
Entrez Gene	8994
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	LIM domains containing 1
Other Description	LIM domain-containing protein 1
Swissprots	Q9NQ47 Q9BQQ9 Q17RQ1 Q9UGP4
Accessions	CAB95944 CAC35917 EAW64742 Q9UGP4 AJ132408 CAB63652 AK021508 BC027712 BC117236 AAI17237 BC117238 AAI17239 BU428864 HQ258355 ADR83109 M80651 XM_005265529 XP_005265586 XM_011534207 XP_011532509 NM_014240 NP_055055
Function	Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of T
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down- regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
Tissue Specificity	Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. {ECO:0000269|PubMed:10647888, ECO:0000269|PubMed:18712738}.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LIMD1 full length protein - ab160285 from Abcam Category Protein Source Wheat germ Species Human

Human LIMD1 protein fragment - ab160286 from Abcam Category Protein Source Wheat germ Species Human

LIMD1 Antibody Blocking Peptide - LS-E2210 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIMD1 Antibody Blocking Peptide - LS-E18255 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LIMD1 Protein - H00008994-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LIMD1 Protein - H00008994-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LIMD1-Antibody-C-term-Blocking-Peptide - BP13132b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LIMD1 Blocking Peptide - 33R-5846 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LIMD1 - H00008994-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LIMD1 - H00008994-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LIMD1 - H00008994-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LIMD1 - H00008994-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Recombinant Human LIM domain-containing protein 1(LIMD1) - CSB-YP883381HU CSB-EP883381HU CSB-BP883381HU CSB-MP883381HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LIMD1 - TP322723 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LIMD1 Peptide, Human - M34GP08714H from Creative Peptides Category Peptide Source Synthetic. Species Human

LIMD1 Recombinant Protein Antigen - NBP2-56448PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

LIM domain-containing protein 1 (LIMD1), Recombinant Protein - MBS1414402 from MyBioSource Category Protein Prices $1,480.00, $1,480.00, $1,710.00, $1,710.00, $2,520.00, $2,520.00, $2,965.00, $2,965.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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