| Gene Symbol |
LIMD1
|
| Entrez Gene |
8994
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LIM domains containing 1
|
| Other Description |
LIM domain-containing protein 1
|
| Swissprots |
Q9NQ47 Q9BQQ9 Q17RQ1 Q9UGP4
|
| Accessions |
CAB95944 CAC35917 EAW64742 Q9UGP4 AJ132408 CAB63652 AK021508 BC027712 BC117236 AAI17237 BC117238 AAI17239 BU428864 HQ258355 ADR83109 M80651 XM_005265529 XP_005265586 XM_011534207 XP_011532509 NM_014240 NP_055055
|
| Function |
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of T
|
| Subcellular Location |
Cytoplasm. Nucleus. Cytoplasm, P-body. Cell junction, adherens junction. Cell junction, focal adhesion. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions. Down- regulation and/or elimination of its expression from the nucleus of neoplastic cells correlates strongly with poor patient prognosis and aggressive forms of breast carcinoma. Conversely, strong nuclear localization correlates with low-tumor grade and better patient prognosis.
|
| Tissue Specificity |
Expressed in normal and breast cancer tissues (at protein level). Ubiquitous. {ECO:0000269|PubMed:10647888, ECO:0000269|PubMed:18712738}.
|
| Top Pathways |
Hippo signaling pathway
|