Gene Symbol | STX1A |
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Entrez Gene | 6804 |
Alt Symbol | HPC-1, P35-1, STX1, SYN1A |
Species | Human |
Gene Type | protein-coding |
Description | syntaxin 1A (brain) |
Other Description | neuron-specific antigen HPC-1|syntaxin-1A |
Swissprots | O15447 Q16623 Q12936 Q9BPZ6 Q75MD9 Q7Z5K3 O15448 |
Accessions | AAB65500 AAK54507 AAS07469 AAS07470 EAW69649 EAW69650 EAW69651 EAW69652 EAW69653 EAW69654 EAW69655 Q16623 AB086954 BAC78519 AI951874 AK299959 BAG61785 AK313980 BAG36694 BC000444 BC003011 AAH03011 BC064644 AAH64644 CR457018 CAG33299 D37932 BAA07151 DA159446 GQ129291 ACT64425 GQ129292 ACT64426 KJ534952 AHW56592 KJ534980 AHW56620 L37792 AAA53519 U12918 AAA20940 XM_011516541 XP_011514843 XR_242263 XR_927527 XR_927528 NM_001165903 NP_001159375 NM_004603 NP_004594 |
Function | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. |
Tissue Specificity | Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. {ECO:0000269|PubMed:10644452}. |
Top Pathways | Synaptic vesicle cycle, Amphetamine addiction, SNARE interactions in vesicular transport |
Syntaxin 1A CRISPR/Cas9 KO Plasmid (h) - sc-418295 from Santa Cruz Biotechnology
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Syntaxin 1A HDR Plasmid (h) - sc-418295-HDR from Santa Cruz Biotechnology
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Syntaxin 1A Double Nickase Plasmid (h) - sc-418295-NIC from Santa Cruz Biotechnology
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Syntaxin 1A Double Nickase Plasmid (h2) - sc-418295-NIC-2 from Santa Cruz Biotechnology
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Syntaxin 1A CRISPR Activation Plasmid (h) - sc-418295-ACT from Santa Cruz Biotechnology
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Syntaxin 1A CRISPR Activation Plasmid (h2) - sc-418295-ACT-2 from Santa Cruz Biotechnology
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Syntaxin 1A Lentiviral Activation Particles (h) - sc-418295-LAC from Santa Cruz Biotechnology
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Syntaxin 1A Lentiviral Activation Particles (h2) - sc-418295-LAC-2 from Santa Cruz Biotechnology
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Syntaxin 1A siRNA (h) - sc-44136 from Santa Cruz Biotechnology
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Syntaxin 1A shRNA Plasmid (h) - sc-44136-SH from Santa Cruz Biotechnology
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Syntaxin 1A shRNA (h) Lentiviral Particles - sc-44136-V from Santa Cruz Biotechnology
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Syntaxin 1A RNAi - H00006804-R01 from Novus Biologicals
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MISSION® esiRNA - EHU143351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20782 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20782 from Sigma-Aldrich
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STX1A siRNA (Human) - CRH4653 from Cohesion Biosciences
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STX1A - MBS8241200 from MyBioSource
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shRNA set against Human STX1A (NM_004603.3) - SHH420316 from Creative biogene
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Human STX1A siRNA - orb265155 from Biorbyt
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STX1A shRNA Plasmid (Human) - CHH4653 from Cohesion Biosciences
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STX1A miRNA 3'UTR clone - MiUTR3H-02162 from Creative biogene
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STX1A miRNA 3'UTR clone - MiUTR3H-02163 from Creative biogene
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